Research on the stimulus properties of drugs began with studies on state dependent
learning during the first half of the twentieth century. From that research, an entirely new …

Background Drug discrimination is an increasingly valuable behavioral assay for the
preclinical development of antipsychotic drugs. The majority of studies have used the …

Rationale The sacred lotus (Nelumbo nucifera) contains many phytochemicals and has a
history of human use. To determine which compounds may be responsible for reported …

Primarily, rats have served as subjects in Δ9-tetrahydrocannabinol's (THC) discrimination
studies although other species such as monkeys and pigeons have been used. While the …

The immediate-early gene early growth response 3 (Egr3) is associated with schizophrenia
and expressed at reduced levels in postmortem patients' brains. We have previously …

Abstract Rationale Racemic (RS)-amisulpride (Solian®) is an atypical antipsychotic drug
used to treat schizophrenia and dysthymia. Blockade of dopamine D 2/D 3 and/or serotonin …

RATIONALE: Drug-induced stimulus control has proven to be a powerful tool for the
assessment of a wide range of psychoactive drugs. Although a variety of species has been …

RATIONALE: Based upon extensive studies in the rat, it has been suggested that stimulus
control by LSD is mediated by 5-HT2A receptors, with serotonergic receptors of the 5-HT1A …

Amisulpride, a substituted benzamide derivative, exerts atypical antipsychotic and
antidepressant clinical effects and its (S)-stereoisomer is thought to underlie these actions …

Rationale The discriminative stimulus properties of the atypical antipsychotic drug (APD)
clozapine (CLZ) have recently been studied in C57BL/6 mice, a common background strain …