Morin as an imminent functional food ingredient: An update on its enhanced efficacy in the treatment and prevention of metabolic syndromes

K Thakur, YY Zhu, JY Feng, JG Zhang, F Hu… - Food & function, 2020 - pubs.rsc.org
Flavonoids represent polyphenolic plant secondary metabolites with a general structure of a
15-carbon skeleton comprising two phenyl rings and a heterocyclic ring. Over 5000 natural …

Alternative therapy of psychosis: Potential phytochemicals and drug targets in the management of schizophrenia

A Saleem, MF Akhtar - Frontiers in pharmacology, 2022 - frontiersin.org
Schizophrenia is a chronic mental and behavioral disorder characterized by clusters of
symptoms including hallucinations, delusions, disorganized thoughts and social withdrawal …

Lipopolysaccharide exacerbates ketamine-induced psychotic-like behavior, oxidative stress, and neuroinflammation in mice: ameliorative effect of diosmin

AEO Eneni, B Ben-Azu, AM Ajayi… - Journal of Molecular …, 2023 - Springer
Schizophrenia, a neuropsychiatric disorder has been associated with aberrant
neurotransmission affecting behaviors, social preference, and cognition. Limitations in …

Mechanisms underpinning Carpolobia lutea G. Don ethanol extract's neurorestorative and antipsychotic-like activities in an NMDA receptor antagonist model of …

NA Omeiza, A Bakre, B Ben-Azu, AA Sowunmi… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Persistent ketamine insults to the central nervous system
block NMDA receptors and disrupt putative neurotransmission, oxido–nitrosative, and …

Morin decreases cortical pyramidal neuron degeneration via inhibition of neuroinflammation in mouse model of schizophrenia

B Ben-Azu, AO Aderibigbe, AM Ajayi, AEO Eneni… - International …, 2019 - Elsevier
Neuroinflammation plays a prominent role in the pathophysiology and progression of
schizophrenia. Thus, suppression of neuroinflammation may retard the progression of the …

Repeated psychosocial stress causes glutamic acid decarboxylase isoform-67, oxidative-Nox-2 changes and neuroinflammation in mice: prevention by treatment with …

B Ben-Azu, O Emokpae, AM Ajayi, TA Jarikre… - Brain research, 2020 - Elsevier
Psychosocial stress and biological predispositions are linked to mood and personality
disorders related to psychiatric behaviors. Targeting neuroinflammation and oxidative stress …

[HTML][HTML] Probable mechanisms involved in the antipsychotic-like activity of morin in mice

B Ben-Azu, AO Aderibigbe, IA Omogbiya… - Biomedicine & …, 2018 - Elsevier
Evidence derived from preliminary studies suggests that morin, a neuroactive flavonoid with
proven antioxidant and antiinflammatory properties possess antipsychotic-like activity. The …

Involvement of GABAergic, BDNF and Nox-2 mechanisms in the prevention and reversal of ketamine-induced schizophrenia-like behavior by morin in mice

B Ben-Azu, AO Aderibigbe, AM Ajayi, AEO Eneni… - Brain Research …, 2018 - Elsevier
GABAergic (Gamma-aminobutyric acid) and neurotrophic derangements have important
implication in schizophrenia, a neuropsychiatric disease. Previous studies have shown that …

Morin attenuates neurochemical changes and increased oxidative/nitrergic stress in brains of mice exposed to ketamine: prevention and reversal of schizophrenia-like …

B Ben-Azu, AO Aderibigbe, AEO Eneni, AM Ajayi… - Neurochemical …, 2018 - Springer
Previous studies have revealed that morin (MOR), a neuroactive bioflavonoid, with proven
psychotropic and neuroprotective properties reduced schizophrenic-like behaviors in mice …

Effective action of silymarin against ketamine-induced schizophrenia in male mice: Insight into the biochemical and molecular mechanisms of action

B Ben-Azu, AR Fokoua, OS Annafi, OG Adebayo… - Journal of Psychiatric …, 2024 - Elsevier
Background Neurochemical dysregulations resulting from N-methyl-D-aspartate
hypofunction (NMDA), are exacerbated by neuroimmune and oxidative stress and are …