Forces are increasingly recognized as major regulators of cell structure and function, and
the mechanical properties of cells are essential to the mechanisms by which cells sense …

Recent studies have revealed unexpected connections between the mammalian Hedgehog
(Hh) signal transduction pathway and the primary cilium, a microtubule-based organelle that …

Cilia, as motile and sensory organelles, have been implicated in normal development, as
well as diseases including cystic kidney disease, hydrocephalus and situs inversus. In …

Recent findings show that cilia are sensory organelles that display specific receptors and ion
channels, which transmit signals from the extracellular environment via the cilium to the cell …

Background—When challenged with extracellular fluid shear stress, vascular endothelial
cells are known to release nitric oxide, an important vasodilator. Here, we show that the …

The establishment of left-right asymmetry in mammals is a good example of how multiple
cell biological processes coordinate in the formation of a basic body plan. The leftward …

The primary cilium acts as a transducer of extracellular stimuli into intracellular signaling [1,
2]. Its regulation, particularly with respect to length, has been defined primarily by genetic …

Animals use their gustatory systems to evaluate the nutritious value, toxicity, sodium content,
and acidity of food. Although characterization of molecular identities that receive taste …

A current challenge in neuroscience is to bridge the gaps between genes, proteins, neurons,
neural circuits, and behavior in a single animal model. The nematode Caenorhabditis …

When we edited in 2007 the first issue on transient receptor potential channel in the
Handbook of Experimental Pharmacology, we were all very excited by the progress in this …