Animals assemble and maintain a diverse but host-specific gut microbial community. In
addition to characteristic microbial compositions along the longitudinal axis of the intestines …

Escherichia coli is the predominant nonpathogenic facultative flora of the human intestine.
Some E. coli strains, however, have developed the ability to cause disease of the …

The microbiota-gut-brain axis is a bidirectional communication system that is poorly
understood. Alzheimer's disease (AD), the most common cause of dementia, has long been …

Salmonella enterica subspecies 1 serovar Typhimurium is a principal cause of human
enterocolitis. For unknown reasons, in mice serovar Typhimurium does not provoke …

Salmonella species cause substantial morbidity, mortality and burden of disease globally.
Infections with Salmonella species cause multiple clinical syndromes. Central to the …

Bacterial pathogens employ a number of genetic strategies to cause infection and,
occasionally, disease in their hosts. Many of these virulence factors and their regulatory …

The human gut microflora is important in regulating host inflammatory responses and in
maintaining immune homeostasis. The cellular and molecular bases of these actions are …

The effects of pathogenic organisms on host intestinal epithelial cells are vast. Innumerable
signalling pathways are triggered leading ultimately to drastic changes in physiological …

Pathogenic bacteria that penetrate the intestinal epithelial barrier stimulate an inflammatory
response in the adjacent intestinal mucosa. The present studies asked whether colon …

Salmonella enterica (S. enterica) are Gram-negative bacteria that can invade a broad range
of hosts causing both acute and chronic infections. This phenotype is related to its ability to …