The Mediterranean diet (MedDiet) is one of the most widely described and evaluated dietary
patterns in scientific literature. It is characterized by high intakes of vegetables, legumes …

In the era of molecular biology our understanding of subcellular processes that ultimately
lead to inflammatory bowel disease or colorectal cancer has widened considerably. The …

Sulforaphane (SFN), a compound found at high levels in broccoli and broccoli sprouts, is a
potent inducer of phase 2 detoxification enzymes and inhibits tumorigenesis in animal …

We recently reported that sulforaphane (SFN), an isothiocyanate from broccoli, inhibited
HDAC activity and increased the acetylation of histone H3 and histone H4 in human colon …

Sulforaphane (SFN), an isothiocyanate first isolated from broccoli, exhibits chemopreventive
properties in prostate cancer cells through mechanisms that are poorly understood. We …

Preclinical studies with the histone deacetylase (HDAC) inhibitor depsipeptide (FK228) in
chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) have demonstrated …

Colorectal cancer (CRC) is the third most common cancer diagnosis and the second and
third leading cause of cancer mortality in men and women, respectively. However, the …

Butyrate, a short‐chain fatty acid produced by the colonic bacterial fermentation is able to
induce cell growth inhibition and differentiation in colon cancer cells at least partially through …

Histone deacetylase (HDAC) inhibitors promote cell maturation, differentiation, and
apoptosis through changes in gene expression. Differentiated epithelial cells are …

Histone deacetylase (HDAC) inhibitors have the potential to derepress epigenetically
silenced genes in cancer cells, leading to cell cycle arrest and apoptosis. In the present …