Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

Functional and molecular analysis of glial voltage-and ligand-gated ion channels underwent
tremendous boost over the last 15 years. The traditional image of the glial cell as a passive …

The subcortical white matter of the adult human brain harbors a pool of glial progenitor cells.
These cells can be isolated by fluorescence-activated cell sorting (FACS) after either …

Neurogenesis persists in the adult mammalian hippocampus. To identify and isolate
neuronal progenitor cells of the adult human hippocampus, we transfected ventricular zone …

Recent data have suggested the existence of direct signaling pathways between glial cells
and neurons. Here we report the coexistence of distinct types of cells expressing astrocyte …

Ions in the brain are regulated independently from plasma levels by active transport across
choroid plexus epithelium and cerebral capillary endothelium, assisted by astrocytes. In …

Functional properties of astrocytes were investigated with the patchclamp technique in
acute hippocampal brain slices obtained from surgical specimens of patients suffering from …

Glial cells, although nonexcitable, express a wealth of voltageactivated ion channels that
are typically characteristic of excitable cells. Since these channels are also observed in …

It is established that astrocytes are the intimate partner of neurons throughout their lifespan.
However, astrocytes play different roles at different stages of the lifespan. During …

Leukocyte infiltration in the CNS after trauma or inflammation is triggered in part by
upregulation of the chemokine, monocyte chemoattractant protein-1 (MCP-1), in astrocytes …