ADP-ribosylation (ADPRylation) is a post-translational modification of proteins catalyzed by
ADP-ribosyl transferase (ART) enzymes, including nuclear PARPs (eg, PARP1 and PARP2) …

Abstract Poly (ADP-ribosyl) ation (PARylation) is posttranslational modification of proteins by
linear or branched chains of ADP-ribose units, originating from NAD+. The central enzyme …

Abstract Poly (ADP-ribose) polymerase (PARP) enzymes are broadly involved in the cellular
response to DNA damage. PARP-1 is the chief human PARP enzyme involved in the DNA …

RNA function relies heavily on posttranscriptional modifications. Recently, it was shown that
certain PARPs and TRPT1 can ADP-ribosylate RNA in vitro. Traditionally, intracellular ADP …

ADP-ribosylation is an intricate and versatile posttranslational modification involved in the
regulation of a vast variety of cellular processes in all kingdoms of life. Its complexity derives …

The numerous biological roles of NAD+ are organized and coordinated via its
compartmentalization within cells. The spatial and temporal partitioning of this intermediary …

ADP-ribosylation is a chemical modification of macromolecules found across all domains of
life and known to regulate a variety of cellular processes. Notably, it has a well-established …

Protein ADP-ribosylation is essential for the regulation of several cellular pathways,
enabling dynamic responses to diverse pathophysiological conditions. It is modulated …

Although ubiquitylation had traditionally been considered limited to proteins, the discovery of
non-proteinaceous substrates (eg lipopolysaccharides and adenosine diphosphate ribose …

ADP-ribosyltransferases use NAD+ to catalyse substrate ADP-ribosylation, and thereby
regulate cellular pathways or contribute to toxin-mediated pathogenicity of bacteria …