Multiscale modeling of the neuromuscular system: coupling neurophysiology and skeletal muscle mechanics

O Röhrle, UŞ Yavuz, T Klotz, F Negro… - … : Systems Biology and …, 2019 - Wiley Online Library
Mathematical models and computer simulations have the great potential to substantially
increase our understanding of the biophysical behavior of the neuromuscular system. This …

Investigating the spatial resolution of EMG and MMG based on a systemic multi-scale model

T Klotz, L Gizzi, O Röhrle - Biomechanics and Modeling in …, 2022 - Springer
While electromyography (EMG) and magnetomyography (MMG) are both methods to
measure the electrical activity of skeletal muscles, no systematic comparison between both …

An efficient modelling-simulation-analysis workflow to investigate stump-socket interaction using patient-specific, three-dimensional, continuum-mechanical, finite …

E Ramasamy, O Avci, B Dorow, SY Chong… - … in bioengineering and …, 2018 - frontiersin.org
The lack of an efficient modelling-simulation-analysis workflow for creating and utilising
detailed subject-specific computational models is one of the key reasons why simulation …

Characterization of electromechanical delay based on a biophysical multi-scale skeletal muscle model

L Schmid, T Klotz, T Siebert, O Röhrle - Frontiers in Physiology, 2019 - frontiersin.org
Skeletal muscles can be voluntary controlled by the somatic nervous system yielding an
active contractile stress response. Thereby, the active muscle stresses are transmitted to the …

Multiscale mechanical modeling of skeletal muscle: a systemic review of the literature

A Loumeaud, P Pouletaut, SF Bensamoun… - Journal of Medical and …, 2024 - Springer
Purpose From the myofibrils to the whole muscle scale, muscle micro-constituents exhibit
passive and active mechanical properties, potentially coupled to electrical, chemical, and …

MegaMol–a comprehensive prototyping framework for visualizations

P Gralka, M Becher, M Braun, F Frieß, C Müller… - The European Physical …, 2019 - Springer
We present MegaMol, a low-overhead prototyping framework for interactive visualization of
large scientific data sets. We give a brief summary of related work for context and then focus …

Modelling the electrical activity of skeletal muscle tissue using a multi-domain approach

T Klotz, L Gizzi, UŞ Yavuz, O Röhrle - Biomechanics and modeling in …, 2020 - Springer
Electromyography (EMG) can be used to study the behaviour of the motor neurons and thus
provides insights into the physiology of the central nervous system. However, due to the high …

[HTML][HTML] OpenDiHu: an efficient and scalable framework for biophysical simulations of the neuromuscular system

B Maier, D Göddeke, F Huber, T Klotz, O Röhrle… - Journal of …, 2024 - Elsevier
The versatile neuromuscular system, consisting of skeletal muscles and the nervous system,
enables human to perform crucial everyday tasks. To investigate its functioning and …

Knowledge-based modeling of simulation behavior for Bayesian optimization

F Huber, PC Bürkner, D Göddeke, M Schulte - Computational Mechanics, 2024 - Springer
Numerical simulations consist of many components that affect the simulation accuracy and
the required computational resources. However, finding an optimal combination of …

[HTML][HTML] Mesh generation and multi-scale simulation of a contracting muscle–tendon complex

B Maier, M Schulte - Journal of Computational Science, 2022 - Elsevier
The multi-scale character of skeletal muscle models requires simulations with high spatial
resolution to capture all relevant effects. This naturally involves high computational load that …