Localized scleroderma (LS) is a complex disease characterized by a mixture of inflammation
and fibrosis of the skin that, especially in the pediatric population, also affects …

Skin autoimmune conditions belong to a larger group of connective tissue diseases and
primarily affect the skin, but might also involve underlying tissues, such as fat tissue, muscle …

Objective The aim of this study was to evaluate factors associated with extracutaneous
involvement (ECI) in juvenile localized scleroderma (jLS). Methods A prospective …

Objective To evaluate the safety and efficacy of abatacept treatment for refractory juvenile
localized scleroderma (jLS) in a retrospective study. Methods A multicentre cohort study was …

Background Localized scleroderma (LS) is a rare chronic immune-mediated skin condition
of unknown etiology characterized by an inflammatory response in the skin and …

Localized scleroderma (LS), also known as morphea, is an idiopathic inflammatory and
sclerosing disorder affecting the skin and subcutaneous structures. 1, 2 Although skin …

Background Paediatric localized scleroderma is a severe inflammatory disorder associated
with tissue atrophy, often leading to disability. Assessing disease activity and response to …

Background Juvenile localized scleroderma (JLS) is a rare pediatric disease characterized
by inflammation and skin thickening. JLS is associated with deep tissue and extracutaneous …

Clinical evaluation, both physical exam and history, is the most important aspect in
diagnosing and assessing activity of linear scleroderma. Clinical scoring methods may be …

Suzanne C. Li, MD, PhD1, Kathleen M. O'Neil, MD2, and Gloria C. Higgins, MD, PhD3
Juvenile localized scleroderma, also called morphea, is a chronic autoimmune and fibrosing …