Natural killer (NK) cells have crucial roles in the innate immunosurveillance of cancer and
viral infections. They are 'first responders' that can spontaneously recognize abnormal cells …

Interleukin-12 (IL-12) is a potent, pro-inflammatory type 1 cytokine that has long been
studied as a potential immunotherapy for cancer. Unfortunately, IL-12's remarkable …

Cytokines are a class of potent immunoregulatory proteins that are secreted in response to
various stimuli and act locally to regulate many aspects of human physiology and disease …

Glioblastoma is a poorly immunogenic cancer, and the successes with recent
immunotherapies in extracranial malignancies have, so far, not been translated to this …

Poorly inflamed carcinomas do not respond well to immune checkpoint blockade.
Converting the tumour microenvironment into a functionally inflamed immune hub would …

Bispecific antibodies and asymmetric Fc fusion proteins offer opportunities for important
advances in therapeutics. Bivalent IgG depends upon in vivo dimerization of its heavy …

Several cytokines have been investigated in clinical trials, based on their potent therapeutic
activity observed in animal models of cancer and other diseases. However, substantial …

Targeted delivery of IL-12 might turn this cytokine into a safer, more effective cancer
therapeutic. Here we describe a novel immunocytokine, NHS-IL12, consisting of two …

Cytokines have long been used for therapeutic applications in cancer patients. Substantial
side effects and unfavorable pharmacokinetics limit their application and may prevent dose …

The potent antitumor activity of certain cytokines is often achieved at the expense of
unacceptable toxicity. One avenue to improve the therapeutic index of cytokines in cancer …