Considering highly valuable biological and pharmaceutical properties of coumarins, the
synthesis of these heterocycles has been considered for many organic and pharmaceutical …

Urease is a metalloenzyme including two Ni2+ ions, found in some plants, bacteria, fungi,
microorganisms, invertebrate animals, and animal tissues. Urease acts as a significant …

The urease enzyme has been an important target for the discovery of effective
pharmacological and agricultural products. Thirteen regio-selectively alkylated …

Nineteen biscoumarins were synthesized, well-characterized, and evaluated against α-
glucosidases in vitro. Of these, six compounds (10, 12, 16, and 17–19) were newly …

Humic acid, a biodegradable, non‐toxic and easily accessible high molecular weight
organocatalyst has been explored for the straightforward and environmentally benign …

Thimerosal (TH), an organomercurial compound, is used as a preservative in vaccines and
cosmetics. Its interaction with human hemoglobin (Hb) was investigated under physiological …

Abstract Coumarins (2 H-1-benzopyran-2-ones) are an important group of biological
heterocyclic compounds present in various parts of many plant species, encompassing an …

Urease enzyme is responsible to catalyze the hydrolysis of urea into carbamate and
ammonia. Then carbamate hydrolyzed to ammonia and carbon dioxide. Excess release of …

A new series of metronidazole-1, 2, 3-triazole derivatives 6a–o was synthesized and
evaluated as Helicobacter pylori urease inhibitors. All the synthesized compounds were …

In this study, fragment‐based dynamic combinatorial chemistry (DCC) was explored for the
development of novel urease inhibitors. Based on a rationally designed fragment, two …