Background Ketamine appears to have a therapeutic role in certain mental disorders, most
notably depression. However, the comparative performance of different formulations of …

Mood disorders are common, chronic, recurrent mental illnesses that affect the lives of
millions of individuals worldwide. To date, the monoaminergic systems (serotonergic …

The Canadian Network for Mood and Anxiety Treatments (CANMAT) previously published
treatment guidelines for bipolar disorder in 2005, along with international commentaries and …

Context Existing therapies for bipolar depression have a considerable lag of onset of action.
Pharmacological strategies that produce rapid antidepressant effects—for instance, within a …

Context Existing therapies for major depression have a lag of onset of action of several
weeks, resulting in considerable morbidity. Exploring pharmacological strategies that have …

Obsessive compulsive disorder is prevalent, disabling, incompletely understood, and often
resistant to current therapies. Established treatments consist of specialized cognitive …

In mood disorders, there is growing evidence for glutamatergic abnormalities derived from
peripheral measures of glutamatergic metabolites in patients, postmortem studies on …

Beside the well-known deficiency in serotonergic neurotransmission as pathophysiological
correlate of major depression (MD), recent evidence points to a pivotal role of increased …

Objective We investigated the comparative efficacy and tolerability of pharmacological
treatment strategies for the treatment of acute bipolar depression. Data sources A systematic …

Since publication of the first randomized controlled trial describing rapid antidepressant
effects of ketamine, several reports have confirmed the potential utility of this dissociative …