We have analyzed host cell genes linked to HIV replication that were identified in nine
genome-wide studies, including three independent siRNA screens. Overlaps among the …

Cancer metastasis is a major clinical problem that contributes to unsuccessful therapy.
Augmenting evidence indicates that metastasizing cancer cells employ several mechanisms …

HIV-1 entry requires the cell surface expression of CD4 and either the CCR5 or CXCR4
coreceptors on host cells. Individuals homozygous for the ccr5Δ32 polymorphism do not …

An emerging number of non-chemokine mediators are found to bind to classical chemokine
receptors and to elicit critical biological responses. Macrophage migration inhibitory factor …

Sexual transmission of human immunodeficiency virus type 1 (HIV-1) across mucosal
barriers is responsible for the vast majority of new infections. This relatively inefficient …

The overexpression of macrophage migration inhibitory factor (MIF) has been observed in
many tumors and is implicated in oncogenic transformation and tumor progression. MIF …

Mutations in GJB2 (gap junction protein, beta-2) are the major cause of autosomal recessive
non-syndromic hearing loss. A few allele variants of this gene also cause autosomal …

We have investigated the mechanism of resistance of a HIV type 1 (HIV-1) R5 primary
isolate, D1/85.16, to the small molecule CCR5 inhibitor, vicriviroc (VVC). Unlike other …

As with many immunopathologically driven diseases, the malignant T cells of cutaneous T-
cell lymphomas (CTCLs), such as Sézary syndrome, display aberrant cytokine secretion …

The rapid replication rate of HIV‐1 RNA and its inherent genetic variation have led to the
production of many HIV‐1 variants with decreased drug susceptibility. The capacity of HIV to …