Regulatory activities of transposable elements: from conflicts to benefits
Transposable elements (TEs) are a prolific source of tightly regulated, biochemically active
non-coding elements, such as transcription factor-binding sites and non-coding RNAs. Many …
non-coding elements, such as transcription factor-binding sites and non-coding RNAs. Many …
piRNAs: from biogenesis to function
EM Weick, EA Miska - Development, 2014 - journals.biologists.com
Distinguishing self from non-self plays a crucial role in safeguarding the germlines of
metazoa from mobile DNA elements. Since their discovery less than a decade ago, Piwi …
metazoa from mobile DNA elements. Since their discovery less than a decade ago, Piwi …
TEtranscripts: a package for including transposable elements in differential expression analysis of RNA-seq datasets
Y Jin, OH Tam, E Paniagua, M Hammell - Bioinformatics, 2015 - academic.oup.com
Motivation: Most RNA-seq data analysis software packages are not designed to handle the
complexities involved in properly apportioning short sequencing reads to highly repetitive …
complexities involved in properly apportioning short sequencing reads to highly repetitive …
Modeling of TREX1-dependent autoimmune disease using human stem cells highlights L1 accumulation as a source of neuroinflammation
Three-prime repair exonuclease 1 (TREX1) is an anti-viral enzyme that cleaves nucleic
acids in the cytosol, preventing accumulation and a subsequent type I interferon-associated …
acids in the cytosol, preventing accumulation and a subsequent type I interferon-associated …
Tau activates transposable elements in Alzheimer's disease
Aging and neurodegenerative disease are characterized by genomic instability in neurons,
including aberrant activation and mobilization of transposable elements (TEs). Integrating …
including aberrant activation and mobilization of transposable elements (TEs). Integrating …
Ubiquitous L1 mosaicism in hippocampal neurons
Summary Somatic LINE-1 (L1) retrotransposition during neurogenesis is a potential source
of genotypic variation among neurons. As a neurogenic niche, the hippocampus supports …
of genotypic variation among neurons. As a neurogenic niche, the hippocampus supports …
PIWI proteins and PIWI-interacting RNAs in the soma
RJ Ross, MM Weiner, H Lin - Nature, 2014 - nature.com
The discovery of millions of PIWI-interacting RNAs revealed a fascinating and unanticipated
dimension of biology. The PIWI–piRNA pathway has been commonly perceived as germline …
dimension of biology. The PIWI–piRNA pathway has been commonly perceived as germline …
Pan-arthropod analysis reveals somatic piRNAs as an ancestral defence against transposable elements
In animals, small RNA molecules termed PIWI-interacting RNAs (piRNAs) silence
transposable elements (TEs), protecting the germline from genomic instability and mutation …
transposable elements (TEs), protecting the germline from genomic instability and mutation …
The influence of LINE‐1 and SINE retrotransposons on mammalian genomes
SR Richardson, AJ Doucet, HC Kopera… - Mobile DNA …, 2015 - Wiley Online Library
Transposable elements (TEs) or “jumping genes” historically have been disparaged as a
class of “junk DNA” in mammalian genomes (1, 2). The advent of whole genome DNA …
class of “junk DNA” in mammalian genomes (1, 2). The advent of whole genome DNA …
Chromatin accessibility: methods, mechanisms, and biological insights
AR Mansisidor, VI Risca - Nucleus, 2022 - Taylor & Francis
Access to DNA is a prerequisite to the execution of essential cellular processes that include
transcription, replication, chromosomal segregation, and DNA repair. How the proteins that …
transcription, replication, chromosomal segregation, and DNA repair. How the proteins that …