Tranexamic acid for preventing postpartum haemorrhage

N Novikova, GJ Hofmeyr… - Cochrane Database of …, 2015 - cochranelibrary.com
Background Postpartum haemorrhage (PPH) is a common and potentially life‐threatening
complication of labour. Several options for preventing PPH are available, but further …

Tranexamic acid in hip and knee arthroplasty

JS Melvin, LS Stryker, RJ Sierra - JAAOS-Journal of the American …, 2015 - journals.lww.com
Perioperative blood loss is a significant concern for patients undergoing total joint
arthroplasty. A growing body of evidence has shown tranexamic acid (TXA) to be effective in …

Topical intra-articular compared with intravenous tranexamic acid to reduce blood loss in primary total knee replacement: a double-blind, randomized, controlled …

E Gomez-Barrena, M Ortega-Andreu… - JBJS, 2014 - journals.lww.com
Background: Abundant literature regarding the use of intravenous tranexamic acid (TXA) in
primary total knee replacement is available. Randomized controlled trials have confirmed …

[HTML][HTML] Cemented versus cementless total knee arthroplasty of the same modern design: a prospective, randomized trial

D Nam, CM Lawrie, R Salih, CR Nahhas, RL Barrack… - JBJS, 2019 - journals.lww.com
Background: Highly porous surfaces promoting biologic fixation have renewed interest in
cementless total knee arthroplasty (TKA), but the potential for failed biologic fixation remains …

The safety of tranexamic acid in total joint arthroplasty: a direct meta-analysis

YA Fillingham, DB Ramkumar, DS Jevsevar… - The Journal of …, 2018 - Elsevier
Background Tranexamic acid (TXA) is effective in reducing blood loss in total joint
arthroplasty (TJA), but concerns still remain regarding the drug's safety. The purpose of this …

A prospective double-blind placebo controlled trial of topical tranexamic acid in total knee arthroplasty

AG Georgiadis, SJ Muh, CD Silverton, RM Weir… - The Journal of …, 2013 - Elsevier
Tranexamic acid (TNA) reduces postoperative blood loss in general and obstetrical surgery
but there is limited orthopaedic literature regarding its use in the topical setting. To study the …

Comparing efficacy of three methods of tranexamic acid administration in reducing hemoglobin drop following total knee arthroplasty

MM Sarzaeem, M Razi, G Kazemian… - The Journal of …, 2014 - Elsevier
The ideal method of providing tranexamic acid (TXA) for decreasing hemoglobin drop after
TKA is still controversial. In this clinical trial, 200 patients were randomly allocated to four …

Intravenous versus topical tranexamic acid in total knee arthroplasty: both effective in a randomized clinical trial of 640 patients

MP Abdel, BP Chalmers, MJ Taunton, MW Pagnano… - Jbjs, 2018 - journals.lww.com
Background: Tranexamic acid (TXA) reduces bleeding and the need for transfusion after
total knee arthroplasty. Most literature has focused on intravenous (IV) administration of TXA …

[HTML][HTML] Aspirin and the prevention of venous thromboembolism following total joint arthroplasty: commonly asked questions

I Azboy, R Barrack, AM Thomas… - The Bone & Joint …, 2017 - boneandjoint.org.uk
The number of arthroplasties being performed increases each year. Patients undergoing an
arthroplasty are at risk of venous thromboembolism (VTE) and appropriate prophylaxis has …

[HTML][HTML] Systematic review and meta-analysis of perioperative intravenous tranexamic acid use in spinal surgery

B Yang, H Li, D Wang, X He, C Zhang, P Yang - PloS one, 2013 - journals.plos.org
Background Tranexamic acid (TXA) is well-established as a versatile oral, intramuscular,
and intravenous (IV) antifibrinolytic agent. However, the efficacy of IV TXA in reducing …