Hepatocellular carcinoma (HCC) is an aggressive disease with a poor clinical outcome. The
cancer stem cell (CSC) model states that tumour growth is powered by a subset of tumour …

Cancer divergence has many facets other than being considered a genetic term. It is a
tremendous challenge to understand the metastasis and therapy response in cancer …

Background Metastasis is the main cause of death in colorectal cancer (CRC). Circulating
tumour cells (CTCs) are regarded as the precursor cells of metastasis. The CTCs, which …

Epithelial–mesenchymal transition (EMT) is a program wherein epithelial cells lose their
junctions and polarity while acquiring mesenchymal properties and invasive ability …

Simple Summary Senescence is a form of cell cycle arrest induced by stresses such as DNA
damage and oncogenes and therefore constitutes a crucial barrier against cancer …

Transforming growth factor beta (TGF-β) plays key roles in regulating cellular proliferation
and maintaining tissue homeostasis. TGF-β exerts tumor-suppressive effects in the early …

Abstract βII spectrin, the most common isoform of non-erythrocyte spectrin, is a cytoskeleton
protein present in all nucleated cells. Interestingly, βII spectrin is essential for the …

Production of amphiregulin (Areg) by regulatory T (Treg) cells promotes repair after acute
tissue injury. Here, we examined the function of Treg cells in non-alcoholic steatohepatitis …

Cancer-associated fibroblasts (CAFs) are important components of tumor stroma and play a
key role in tumor progression. CAFs involve in crosstalk with tumor cells through various …

Aesculin, a natural product from the traditional and widely-used Chinese medicine named
Cortex fraxini, has attracted attention as a novel therapeutic modulator of inflammation …