The Wnt signaling pathway is known as one of the important molecular cascades that
regulate cell fate throughout lifespan. The Wnt signaling pathway is further separated into …

The Wnt/β-catenin signaling pathway is one of several key conserved intercellular signaling
pathways in animals, and plays fundamental roles in the proliferation, regeneration …

Winner, 2010 PROSE Award for Excellence in the Biological Sciences. Professional and
Scholarly Publishing division of the Association of American Publishers In this unique book …

Teeth play essential roles in life. Their development relies on reciprocal interactions
between the ectoderm-derived dental epithelium and the underlying neural crest-originated …

Mice carrying mutations in Wise (Sostdc1) display defects in many aspects of tooth
development, including tooth number, size and cusp pattern. To understand the basis of …

Tooth number abnormality is one of the most common dental developmental diseases,
which includes both tooth agenesis and supernumerary teeth. Tooth development is …

Four conserved signaling pathways, including the bone morphogenetic proteins (Bmp),
fibroblast growth factors (Fgf), sonic hedgehog (Shh), and wingless-related (Wnt) pathways …

Supernumerary teeth are common clinical dental anomalies. Although various studies have
provided abundant information regarding genes and signaling pathways involved in tooth …

The Wnt and the bone morphogenic protein (BMP) pathways are evolutionarily conserved
and essentially independent signaling mechanisms, which, however, often regulate similar …

Mammalian teeth develop from oral ectoderm and neural crest derived mesenchyme. The
first morphological sign is the primary dental lamina forming as a thickening of oral …