[HTML][HTML] Molecular and pharmacological aspects of piperine as a potential molecule for disease prevention and management: evidence from clinical trials
Background Piperine is a type of amide alkaloid that exhibits pleiotropic properties like
antioxidant, anticancer, anti-inflammatory, antihypertensive, hepatoprotective …
antioxidant, anticancer, anti-inflammatory, antihypertensive, hepatoprotective …
[HTML][HTML] The promise of Piperine in cancer chemoprevention
Simple Summary With 19.3 million new cancer cases worldwide and nearly 10.0 million
cancer-related deaths cancer is a global health challenge. Cancer is a disease caused by a …
cancer-related deaths cancer is a global health challenge. Cancer is a disease caused by a …
[HTML][HTML] The BCL-2 inhibitor APG-2575 resets tumor-associated macrophages toward the M1 phenotype, promoting a favorable response to anti-PD-1 therapy via …
F Luo, H Li, W Ma, J Cao, Q Chen, F Lu, M Qiu… - Cellular & Molecular …, 2024 - nature.com
The main challenges in the use of immune checkpoint inhibitors (ICIs) are ascribed to the
immunosuppressive tumor microenvironment and the lack of sufficient infiltration of activated …
immunosuppressive tumor microenvironment and the lack of sufficient infiltration of activated …
[HTML][HTML] Molecular dynamics simulation and docking analysis of NF-κB protein binding with sulindac acid
It is of interest to document the Molecular Dynamics Simulation and docking analysis of NF-
κB target with sulindac sodium in combating COVID-19 for further consideration. Sulindac is …
κB target with sulindac sodium in combating COVID-19 for further consideration. Sulindac is …
2, 4-Diaryl-pyrimido [1, 2-a] benzimidazole derivatives as novel anticancer agents endowed with potent anti-leukemia activity: Synthesis, biological evaluation and …
MA Shaldam, D Hendrychová, R El-Haggar… - European Journal of …, 2023 - Elsevier
Acute myeloid leukemia (AML) stands as one of the most aggressive type of human cancer
that can develop rapidly and thus requires immediate management. In the current study, the …
that can develop rapidly and thus requires immediate management. In the current study, the …
PEGylated G4 dendrimers as a promising nanocarrier for piperlongumine delivery: Synthesis, characterization, and anticancer activity
PAMAM dendrimers are well-known delivery vehicles for various therapeutic agents like
synthetic drugs, natural phytoconstituents, and genetic materials. The tunable …
synthetic drugs, natural phytoconstituents, and genetic materials. The tunable …
[HTML][HTML] Betanin improves motor function and alleviates experimental Parkinsonism via downregulation of TLR4/MyD88/NF-κB pathway: molecular docking and …
Parkinson's disease (PD) is a progressive neuroinflammatory and degenerative disease. In
this study, we investigated the neuroprotective action of betanin in the rotenone-induced …
this study, we investigated the neuroprotective action of betanin in the rotenone-induced …
[HTML][HTML] Bioconjugation of Vegetable Oils with UV Absorbers: New Approach in Skin Photoprotection
We reported the tunable synthesis of new vegetable oil–UV filter bioconjugates using sea
buckthorn oil (SBO) and p-methoxycinnamic acid (p-MCA) as an alternative to the common …
buckthorn oil (SBO) and p-methoxycinnamic acid (p-MCA) as an alternative to the common …
[HTML][HTML] A computational–experimental investigation of the molecular mechanism of interleukin-6-piperine interaction
Herein, we elucidate the biophysical aspects of the interaction of an important protein,
Interleukin-6 (IL6), which is involved in cytokine storm syndrome, with a natural product with …
Interleukin-6 (IL6), which is involved in cytokine storm syndrome, with a natural product with …
[HTML][HTML] A novel exchange method to access sulfated molecules
JA Alshehri, AM Benedetti, AM Jones - Scientific reports, 2020 - nature.com
Organosulfates and sulfamates are important classes of bioactive molecules but due to their
polar nature, they are both difficult to prepare and purify. We report an operationally simple …
polar nature, they are both difficult to prepare and purify. We report an operationally simple …