BACKGROUND Infertility is an important side effect of treatments used for cancer and other
non-malignant conditions in males. This may be due to the loss of spermatogonial stem cells …

STUDY QUESTION What clinical practices, patient management strategies and
experimental methods are currently being used to preserve and restore the fertility of …

Testicular tissue cryopreservation is an experimental method to preserve the fertility of
prepubertal patients before they initiate gonadotoxic therapies for cancer or other conditions …

Patients preparing to undergo gonadotoxic medical therapy, radiation therapy, or
gonadectomy should be provided with prompt counseling regarding available options for …

During the last half of the 20th century there have been considerable advancements in
mammalian reproductive technologies, including in vitro production of pre-implantation …

Starting from the period of testis differentiation, the Sertoli cell plays a pivotal role in the
development of a functional testis. FSH is the major mitotic factor for Sertoli cells. Because …

BACKGROUND Fertility in adult life may be severely impaired by gonadotoxic therapies. For
young boys who do not yet produce spermatozoa, cryopreservation of immature testicular …

Human spermatogonia are target for exploration of adult stem cell characteristics and
potential source for the development of therapeutic applications. Almost 50 years ago, Yves …

Infertility is a prevalent condition that has insidious impacts on the infertile individuals, their
families, and society, which extend far beyond the inability to have a biological child …

The majority of children, adolescents, and young adults diagnosed with cancer will become
long-term survivors. Although cancer therapy is associated with many adverse effects, one of …