NMD: a multifaceted response to premature translational termination
S Kervestin, A Jacobson - Nature reviews Molecular cell biology, 2012 - nature.com
Although most mRNA molecules derived from protein-coding genes are destined to be
translated into functional polypeptides, some are eliminated by cellular quality control …
translated into functional polypeptides, some are eliminated by cellular quality control …
Context-specific regulation and function of mRNA alternative polyadenylation
S Mitschka, C Mayr - Nature Reviews Molecular Cell Biology, 2022 - nature.com
Alternative cleavage and polyadenylation (APA) is a widespread mechanism to generate
mRNA isoforms with alternative 3′ untranslated regions (UTRs). The expression of …
mRNA isoforms with alternative 3′ untranslated regions (UTRs). The expression of …
[HTML][HTML] Transcription impacts the efficiency of mRNA translation via co-transcriptional N6-adenosine methylation
B Slobodin, R Han, V Calderone, JAFO Vrielink… - Cell, 2017 - cell.com
Transcription and translation are two main pillars of gene expression. Due to the different
timings, spots of action, and mechanisms of regulation, these processes are mainly …
timings, spots of action, and mechanisms of regulation, these processes are mainly …
RNA structure maps across mammalian cellular compartments
RNA structure is intimately connected to each step of gene expression. Recent advances
have enabled transcriptome-wide maps of RNA secondary structure, called 'RNA …
have enabled transcriptome-wide maps of RNA secondary structure, called 'RNA …
[HTML][HTML] Gene expression is circular: factors for mRNA degradation also foster mRNA synthesis
Maintaining proper mRNA levels is a key aspect in the regulation of gene expression. The
balance between mRNA synthesis and decay determines these levels. We demonstrate that …
balance between mRNA synthesis and decay determines these levels. We demonstrate that …
Comparative dynamic transcriptome analysis (cDTA) reveals mutual feedback between mRNA synthesis and degradation
To monitor eukaryotic mRNA metabolism, we developed comparative dynamic
transcriptome analysis (cDTA). cDTA provides absolute rates of mRNA synthesis and decay …
transcriptome analysis (cDTA). cDTA provides absolute rates of mRNA synthesis and decay …
[HTML][HTML] Single-molecule mRNA decay measurements reveal promoter-regulated mRNA stability in yeast
Messenger RNA decay measurements are typically performed on a population of cells.
However, this approach cannot reveal sufficient complexity to provide information on …
However, this approach cannot reveal sufficient complexity to provide information on …
Defining the RNA interactome by total RNA‐associated protein purification
V Shchepachev, S Bresson, C Spanos… - Molecular systems …, 2019 - embopress.org
The RNA binding proteome (RBP ome) was previously investigated using UV crosslinking
and purification of poly (A)‐associated proteins. However, most cellular transcripts are not …
and purification of poly (A)‐associated proteins. However, most cellular transcripts are not …
The translation elongation factor eEF1A1 couples transcription to translation during heat shock response
Translation elongation factor eEF1A has a well-defined role in protein synthesis. In this
study, we demonstrate a new role for eEF1A: it participates in the entire process of the heat …
study, we demonstrate a new role for eEF1A: it participates in the entire process of the heat …
Ccr4-Not complex: the control freak of eukaryotic cells
The purpose of this review is to provide an analysis of the latest developments on the
functions of the carbon catabolite-repression 4-Not (Ccr4-Not) complex in regulating …
functions of the carbon catabolite-repression 4-Not (Ccr4-Not) complex in regulating …