Intercellular tight junctions represent a formidable barrier against paracellular drug
absorption at epithelia (eg, nasal, intestinal) and the endothelium (eg, blood–brain barrier) …

Multicellular organisms are separated from the external environment by a layer of epithelial
cells whose integrity is maintained by intercellular junctional complexes composed of tight …

A fundamental function of epithelia and endothelia is to separate different compartments
within the organism and to regulate the exchange of substances between them. The tight …

Tight junctions have long been regarded as simple barriers that separate compartments of
different compositions, but recent research indicates that different types of signalling proteins …

The tight junction is an intracellular junctional structure that mediates adhesion between
epithelial cells and is required for epithelial cell function. Tight junctions control paracellular …

ZO (zonula occludens) proteins are scaffolding proteins providing the structural basis for the
assembly of multiprotein complexes at the cytoplasmic surface of intercellular junctions. In …

Tight junctions are the most apical component of the epithelial junctional complex and are
crucial for the formation and functioning of epithelial and endothelial barriers. They regulate …

Cell adhesion is a key regulator of cell differentiation. Cell interactions with neighboring cells
and the extracellular matrix regulate gene expression, cell proliferation, polarity and …

Tight junctions (TJs) are morphologically distinct and highly regulated areas of close contact
between the plasma membranes of neighbouring epithelial and endothelial cells. They are …

Zonula occludens (ZO)-1 was the first tight junction protein to be cloned and has been
implicated as an important scaffold protein. It contains multiple domains that bind a diverse …