Brain energy metabolism: A roadmap for future research
Although we have learned much about how the brain fuels its functions over the last
decades, there remains much still to discover in an organ that is so complex. This article lays …
decades, there remains much still to discover in an organ that is so complex. This article lays …
[HTML][HTML] Metabolic flexibility ensures proper neuronal network function in moderate neuroinflammation
Microglia, brain-resident macrophages, can acquire distinct functional phenotypes, which
are supported by differential reprogramming of cell metabolism. These adaptations include …
are supported by differential reprogramming of cell metabolism. These adaptations include …
Ketogenic diet changes microglial morphology and the hippocampal lipidomic profile differently in stress susceptible versus resistant male mice upon repeated social …
Psychological stress confers an increased risk for several diseases including psychiatric
conditions. The susceptibility to psychological stress is modulated by various factors, many …
conditions. The susceptibility to psychological stress is modulated by various factors, many …
[HTML][HTML] Moderate intrinsic phenotypic alterations in C9orf72 ALS/FTD iPSC-microglia despite the presence of C9orf72 pathological features
I Lorenzini, E Alsop, J Levy, LM Gittings… - Frontiers in cellular …, 2023 - frontiersin.org
While motor and cortical neurons are affected in C9orf72 amyotrophic lateral sclerosis and
frontotemporal dementia (ALS/FTD), it remains largely unknown if and how non-neuronal …
frontotemporal dementia (ALS/FTD), it remains largely unknown if and how non-neuronal …
[HTML][HTML] Microglial activation and priming in Alzheimer's disease: state of the art and future perspectives
Alzheimer's Disease (AD) is the most common cause of dementia, having a remarkable
social and healthcare burden worldwide. Amyloid β (Aβ) and protein Tau aggregates are …
social and healthcare burden worldwide. Amyloid β (Aβ) and protein Tau aggregates are …
High throughput screening identifies auranofin and pentamidine as potent compounds that lower IFN-γ-induced Nitric Oxide and inflammatory responses in mice: DSS …
A Chattopadhyay, JP Joseph, S Jagdish… - International …, 2023 - Elsevier
Abstract Interferon-gamma (IFN-γ) is a type II interferon produced primarily by T cells and
natural killer cells. IFN-γ induces the expression of inducible nitric oxide synthase (NOS2) to …
natural killer cells. IFN-γ induces the expression of inducible nitric oxide synthase (NOS2) to …
[HTML][HTML] Alteration of microglial metabolism and inflammatory profile contributes to neurotoxicity in a hiPSC-derived microglia model of frontotemporal dementia 3
H Haukedal, SS Lorenzen, EW Westi, GI Corsi… - Brain, Behavior, and …, 2023 - Elsevier
Frontotemporal dementia (FTD) is a common cause of early-onset dementia, with no current
treatment options. FTD linked to chromosome 3 (FTD3) is a rare sub-form of the disease …
treatment options. FTD linked to chromosome 3 (FTD3) is a rare sub-form of the disease …
[HTML][HTML] Relevance of tissue-resident memory CD8 T cells in the onset of Parkinson's disease and examination of its possible etiologies: infectious or autoimmune?
O de Fàbregues, M Sellés, D Ramos-Vicente… - Neurobiology of …, 2023 - Elsevier
Tissue-resident memory CD8 T cells are responsible for local immune surveillance in
different tissues, including the brain. They constitute the first line of defense against …
different tissues, including the brain. They constitute the first line of defense against …
Lactate as a supplemental fuel for synaptic transmission and neuronal network oscillations: Potentials and limitations
O Kann - Journal of Neurochemistry, 2024 - Wiley Online Library
Lactate shuttled from the blood circulation, astrocytes, oligodendrocytes or even activated
microglia (resident macrophages) to neurons has been hypothesized to represent a major …
microglia (resident macrophages) to neurons has been hypothesized to represent a major …