Neutrophil extracellular traps in pulmonary diseases: too much of a good thing?

BN Porto, RT Stein - Frontiers in immunology, 2016 - frontiersin.org
Neutrophil extracellular traps (NETs) arise from the release of granular and nuclear contents
of neutrophils in the extracellular space in response to different classes of microorganisms …

Role of respiratory syncytial virus in pediatric pneumonia

S Bianchini, E Silvestri, A Argentiero, V Fainardi, G Pisi… - Microorganisms, 2020 - mdpi.com
Respiratory viral infections represent the leading cause of hospitalization in infants and
young children worldwide and the second leading cause of infant mortality. Among these …

Respiratory Syncytial Virus induces the classical ROS-dependent NETosis through PAD-4 and necroptosis pathways activation

SP Muraro, GF De Souza, SW Gallo, BK Da Silva… - Scientific reports, 2018 - nature.com
Respiratory syncytial virus (RSV) is a major cause of diseases of the respiratory tract in
young children and babies, being mainly associated with bronchiolitis. RSV infection occurs …

Recent progress toward the Discovery of Small molecules as Novel Anti-respiratory Syncytial Virus agents

T Felicetti, C Sarnari, R Gaito, O Tabarrini… - Journal of Medicinal …, 2024 - ACS Publications
Respiratory syncytial virus (RSV) stands as the foremost cause of infant hospitalization
globally, ranking second only to malaria in terms of infant mortality. Although three vaccines …

Host components contributing to respiratory syncytial virus pathogenesis

JJ Carvajal, AM Avellaneda, C Salazar-Ardiles… - Frontiers in …, 2019 - frontiersin.org
Respiratory syncytial virus (RSV) is the most prevalent viral etiological agent of acute
respiratory tract infection. Although RSV affects people of all ages, the disease is more …

A fragile balance: does neutrophil extracellular trap formation drive pulmonary disease progression?

H Block, A Zarbock - Cells, 2021 - mdpi.com
Neutrophils act as the first line of defense during infection and inflammation. Once activated,
they are able to fulfil numerous tasks to fight inflammatory insults while keeping a balanced …

Antiviral Activity of Polymethoxylated Flavones from “Guangchenpi”, the Edible and Medicinal Pericarps of Citrus reticulata 'Chachi'

JJ Xu, X Wu, MM Li, GQ Li, YT Yang… - Journal of agricultural …, 2014 - ACS Publications
The present study found that the supercritical fluid extract of “Guangchenpi” possessed in
vitro antiviral activity against respiratory syncytial virus (RSV). Bioassay-guided isolation and …

Activation of STAT3-mediated ciliated cell survival protects against severe infection by respiratory syncytial virus

C Zhao, Y Bai, W Wang, GM Amonkar, H Mou… - The Journal of Clinical …, 2024 - jci.org
Respiratory syncytial virus (RSV) selectively targets ciliated cells in human bronchial
epithelium and can cause bronchiolitis and pneumonia, mostly in infants. To identify …

Differential responses by human respiratory epithelial cell lines to respiratory syncytial virus reflect distinct patterns of infection control

P Hillyer, R Shepard, M Uehling, M Krenz… - Journal of …, 2018 - Am Soc Microbiol
Respiratory syncytial virus (RSV) infects small foci of respiratory epithelial cells via infected
droplets. Infection induces expression of type I and III interferons (IFNs) and proinflammatory …

The diverse roles of RIP kinases in host-pathogen interactions

VV Eng, MA Wemyss, JS Pearson - Seminars in cell & developmental …, 2021 - Elsevier
Abstract Receptor Interacting Protein Kinases (RIPKs) are cellular signaling molecules that
are critical for homeostatic signaling in both communicable and non-communicable disease …