Capillary forces generated by biomolecular condensates
Liquid–liquid phase separation and related phase transitions have emerged as generic
mechanisms in living cells for the formation of membraneless compartments or biomolecular …
mechanisms in living cells for the formation of membraneless compartments or biomolecular …
The nucleolus as a multiphase liquid condensate
The nucleolus is the most prominent nuclear body and serves a fundamentally important
biological role as a site of ribonucleoprotein particle assembly, primarily dedicated to …
biological role as a site of ribonucleoprotein particle assembly, primarily dedicated to …
[HTML][HTML] Viscoelasticity and advective flow of RNA underlies nucleolar form and function
The nucleolus is the largest biomolecular condensate and facilitates transcription,
processing, and assembly of ribosomal RNA (rRNA). Although nucleolar function is thought …
processing, and assembly of ribosomal RNA (rRNA). Although nucleolar function is thought …
Probing and engineering liquid-phase organelles
Cells compartmentalize their intracellular environment to orchestrate countless
simultaneous biochemical processes. Many intracellular tasks rely on membrane-less …
simultaneous biochemical processes. Many intracellular tasks rely on membrane-less …
[HTML][HTML] Detecting and quantifying liquid–liquid phase separation in living cells by model-free calibrated half-bleaching
F Muzzopappa, J Hummert, M Anfossi… - Nature …, 2022 - nature.com
Cells contain numerous substructures that have been proposed to form via liquid–liquid
phase separation (LLPS). It is currently debated how to reliably distinguish LLPS from other …
phase separation (LLPS). It is currently debated how to reliably distinguish LLPS from other …
[HTML][HTML] Size distributions of intracellular condensates reflect competition between coalescence and nucleation
Phase separation of biomolecules into condensates has emerged as a mechanism for
intracellular organization and affects many intracellular processes, including reaction …
intracellular organization and affects many intracellular processes, including reaction …
Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors
Damage-induced long non-coding RNAs (dilncRNA) synthesized at DNA double-strand
breaks (DSBs) by RNA polymerase II are necessary for DNA-damage-response (DDR) focus …
breaks (DSBs) by RNA polymerase II are necessary for DNA-damage-response (DDR) focus …
[HTML][HTML] Shear relaxation governs fusion dynamics of biomolecular condensates
Phase-separated biomolecular condensates must respond agilely to biochemical and
environmental cues in performing their wide-ranging cellular functions, but our …
environmental cues in performing their wide-ranging cellular functions, but our …
[HTML][HTML] Wetting and complex remodeling of membranes by biomolecular condensates
Cells compartmentalize parts of their interiors into liquid-like condensates, which can be
reconstituted in vitro. Although these condensates interact with membrane-bound …
reconstituted in vitro. Although these condensates interact with membrane-bound …
Chromatin mechanics dictates subdiffusion and coarsening dynamics of embedded condensates
DNA is organized into chromatin, a complex polymeric material which stores information and
controls gene expression. An emerging mechanism for biological organization, particularly …
controls gene expression. An emerging mechanism for biological organization, particularly …