Targeting the progression of chronic kidney disease

M Ruiz-Ortega, S Rayego-Mateos, S Lamas… - Nature Reviews …, 2020 - nature.com
Chronic kidney disease (CKD) is a devastating condition that is reaching epidemic levels
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …

Epigenetic regulation in AKI and kidney repair: mechanisms and therapeutic implications

C Guo, G Dong, X Liang, Z Dong - Nature Reviews Nephrology, 2019 - nature.com
Acute kidney injury (AKI) is a major public health concern associated with high morbidity and
mortality. Despite decades of research, the pathogenesis of AKI remains incompletely …

[HTML][HTML] Non-coding RNAs in kidney injury and repair

Z Liu, Y Wang, S Shu, J Cai… - American Journal of …, 2019 - journals.physiology.org
Acute kidney injury (AKI) is a major kidney disease featured by a rapid decline of renal
function. Pathologically, AKI is characterized by tubular epithelial cell injury and death …

Emerging role of miRNAs in renal fibrosis

Y Fan, H Chen, Z Huang, H Zheng, J Zhou - RNA biology, 2020 - Taylor & Francis
As one type of the most common endogenous short noncoding RNAs (ncRNAs), microRNAs
(miRNAs) act as posttranscriptional regulators of gene expression and have great potential …

[HTML][HTML] TGF-β-mediated upregulation of Sox9 in fibroblast promotes renal fibrosis

H Li, H Cai, J Deng, X Tu, Y Sun, Z Huang… - … Et Biophysica Acta (BBA …, 2018 - Elsevier
TGF-β signaling plays a principal role in renal fibrosis, but the precise mechanisms and the
downstream factors are still largely unknown. Sox9 exhibits diverse roles in regulating the …

Nucleic acid and protein methylation modification in renal diseases

J Jin, X Liu, W Shao, X Meng - Acta Pharmacologica Sinica, 2024 - nature.com
Although great efforts have been made to elucidate the pathological mechanisms of renal
diseases and potential prevention and treatment targets that would allow us to retard kidney …

Ethanol affects behavior and HPA axis activity during development in zebrafish larvae

W Du, X Chen, M Shi, F Bian, Z Zhao - Scientific Reports, 2020 - nature.com
Recent studies have shown that long-term alcohol intake from food can lead to numerous
mental disorders in humans, and the social and health effects of excessive intake of alcohol …

MiR-1247-3p protects rat cardiomyocytes against hypoxia/reoxygenation-induced injury via targeting BCL2L11 and caspase-2

J Huang, Y Huang, Z Feng, W Guo… - Journal of Receptors …, 2021 - Taylor & Francis
Acute myocardial infarction (AMI) represents a severe coronary heart disease with relatively
high rate of mortality and usually can lead to the damage of the myocardial tissues …

[Retracted] Exploring the Effect of Dapagliflozin on Alcoholic Kidney Injury and Renal Interstitial Fibrosis in Rats Based on TIMP‐1/MMP‐24 Pathway

Y Wu, P Song, X Yuan, D Li - Evidence‐Based Complementary …, 2021 - Wiley Online Library
Objective. To establish a rat model of alcoholic kidney injury and detect the expression of
TIMP‐1/MMP‐24 in the kidneys of rats with alcoholic kidney injury at the molecular …

[HTML][HTML] Epigenetic alterations and memory: key players in the development/progression of chronic kidney disease promoted by acute kidney injury and diabetes

I Mimura, Z Chen, R Natarajan - Kidney International, 2024 - Elsevier
Chronic kidney disease (CKD) is a highly prevalent global public health issue and can
progress to renal failure. Survivors of acute kidney injury (AKI) have an increased risk of …