The production of harmful free radicals (H-FRs), especially those with oxygen or nitrogen
atoms, depends on both internal and environmental causes. The negative effects of H-FRs …

The development and response to treatment of tumor are modulated by inflammation, and
chronic inflammation promotes tumor progression and therapy resistance. This article …

Dietary fiber functions as a prebiotic to determine the gut microbe composition. The gut
microbiota influences the metabolic functions and immune responses in human health. The …

Autophagy is an endogenous protective process; the loss of autophagy could destabilize
proteostasis and elevate intracellular oxidative stress, which is critically involved in the …

Copper poses huge environmental and public health concerns due to its widespread and
persistent use in the past several decades. Although it is well established that at higher …

Autophagy is a highly conserved catabolic process involving autolysosomal degradation of
cellular components, including protein aggregates, damaged organelles (such as …

IL-33 is a key mediator of chronic airway disease driven by type 2 immune pathways, yet the
nonclassical secretory mechanism for this cytokine remains undefined. We performed a …

The preservation of cellular homeostasis requires the synthesis of new proteins
(proteostasis) and organelles, and the effective removal of misfolded or impaired proteins …

Chronic obstructive pulmonary disease (COPD), a common and heterogeneous respiratory
disease, is characterized by persistent and incompletely reversible airflow limitation …

Farber disease (FD) and spinal muscular atrophy with progressive myoclonic epilepsy (SMA-
PME) are ultra-rare, autosomal-recessive, acid ceramidase (ACDase) deficiency disorders …