Narcolepsy is a rare brain disorder that reflects a selective loss or dysfunction of orexin (also
known as hypocretin) neurons of the lateral hypothalamus. Narcolepsy type 1 (NT1) is …

Plaguing humans for more than two millennia, manifest on every continent studied, and with
more than one billion patients having an attack in any year, migraine stands as the sixth …

Background Narcolepsy type 1 is caused by severe loss or lack of brain orexin
neuropeptides. Methods We conducted a phase 2, randomized, placebo-controlled trial of …

Abstract Narcolepsy type 1 (NT1) is a chronic sleep disorder resulting from the loss of a
small population of hypothalamic neurons that produce wake-promoting hypocretin (HCRT; …

The recently released third edition of the International Classification of Sleep Disorders
(ICSD) is a fully revised version of the American Academy of Sleep Medicine's manual of …

Orexins (also called hypocretins) are hypothalamic neuropeptides that carry out essential
functions in the central nervous system; however, little is known about their release and …

Insomnia is highly prevalent in clinical practice, occurring in up to 50% of primary care
patients. Insomnia can present independently or alongside other medical conditions or …

Narcolepsy type 1 (NT1) is a sleep disorder caused by a loss of orexinergic neurons.
Narcolepsy type 2 (NT2) is heterogeneous; affected individuals typically have normal orexin …

Narcolepsy with cataplexy is a sleep disorder caused by deficiency in the hypothalamic
neuropeptide hypocretin/orexin (HCRT), unanimously believed to result from autoimmune …

This review summarizes the brain mechanisms controlling sleep and wakefulness.
Wakefulness promoting systems cause low-voltage, fast activity in the …