Fluorescent probes for bioimaging of potential biomarkers in Parkinson's disease
Parkinson's disease (PD), as the second most common neurodegenerative disease, is
caused by complex pathological processes and currently remains very difficult to treat. PD …
caused by complex pathological processes and currently remains very difficult to treat. PD …
[PDF][PDF] -Tropane alkaloids as medicinally useful natural products and their synthetic derivatives as new drugs.
G Grynkiewicz, M Gadzikowska - Pharmacological Reports, 2008 - if-pan.krakow.pl
Secondary metabolites of Solanaceae plants, sharing tropane skeleton as a common
structural feature, are sharply divided into two classes: tropine and ecgonine derivatives …
structural feature, are sharply divided into two classes: tropine and ecgonine derivatives …
Labeling of dopamine transporter transmembrane domain 1 with the tropane ligand N-[4-(4-azido-3-[125I] iodophenyl) butyl]-2β-carbomethoxy-3β-(4-chlorophenyl) …
ML Parnas, JD Gaffaney, MF Zou, JR Lever… - Molecular …, 2008 - ASPET
The novel photoaffinity ligand N-[4-(4-azido-3-125I-iodophenyl)-butyl]-2-β-carbomethoxy-3β-
(4-chlorophenyl) tropane ([125I] MFZ 2-24) was used to investigate the site for cocaine …
(4-chlorophenyl) tropane ([125I] MFZ 2-24) was used to investigate the site for cocaine …
Localization of cocaine analog [125I] RTI 82 irreversible binding to transmembrane domain 6 of the dopamine transporter
RA Vaughan, DS Sakrikar, ML Parnas, S Adkins… - Journal of Biological …, 2007 - ASBMB
The site of cocaine binding on the dopamine transporter (DAT) was investigated using the
photoactivatable irreversible cocaine analog [125 I] 3β-(p-chlorophenyl) tropane-2β …
photoactivatable irreversible cocaine analog [125 I] 3β-(p-chlorophenyl) tropane-2β …
Azido-iodo-N-benzyl derivatives of threo-methylphenidate (Ritalin, Concerta): Rational design, synthesis, pharmacological evaluation, and dopamine transporter …
DJ Lapinsky, R Velagaleti, N Yarravarapu, Y Liu… - Bioorganic & medicinal …, 2011 - Elsevier
In contrast to tropane-based compounds such as benztropine and cocaine, non-tropane-
based photoaffinity ligands for the dopamine transporter (DAT) are relatively unexplored …
based photoaffinity ligands for the dopamine transporter (DAT) are relatively unexplored …
Recognition of psychostimulants, antidepressants, and other inhibitors of synaptic neurotransmitter uptake by the plasma membrane monoamine transporters
CK Surratt, OT Ukairo, S Ramanujapuram - The AAPS journal, 2005 - Springer
The plasma membrane monoamine transporters terminate neurotransmission by removing
dopamine, norepinephrine, or serotonin from the synaptic cleft between neurons. Specific …
dopamine, norepinephrine, or serotonin from the synaptic cleft between neurons. Specific …
(±)-2-(N-tert-Butylamino)-3′-[125I]-iodo-4′-azidopropiophenone: A dopamine transporter and nicotinic acetylcholine receptor photoaffinity ligand based on …
DJ Lapinsky, S Aggarwal, TL Nolan, CK Surratt… - Bioorganic & medicinal …, 2012 - Elsevier
Towards addressing the knowledge gap of how bupropion interacts with the dopamine
transporter (DAT) and nicotinic acetylcholine receptors (nAChRs), a ligand was synthesized …
transporter (DAT) and nicotinic acetylcholine receptors (nAChRs), a ligand was synthesized …
Design and synthesis of a novel photoaffinity ligand for the dopamine and serotonin transporters based on 2β-carbomethoxy-3β-biphenyltropane
AH Newman, JH Cha, J Cao, T Kopajtic… - Journal of medicinal …, 2006 - ACS Publications
Tropane-based photoaffinity ligands covalently bind to discrete points of attachment on the
dopamine transporter (DAT). To further explore structure− activity relations, a ligand in which …
dopamine transporter (DAT). To further explore structure− activity relations, a ligand in which …
A novel photoaffinity ligand for the dopamine transporter based on pyrovalerone
DJ Lapinsky, S Aggarwal, Y Huang, CK Surratt… - Bioorganic & medicinal …, 2009 - Elsevier
Non-tropane-based photoaffinity ligands for the dopamine transporter (DAT) are relatively
unexplored in contrast to tropane-based compounds such as cocaine. In order to fill this …
unexplored in contrast to tropane-based compounds such as cocaine. In order to fill this …
Novel Azido-Iodo Photoaffinity Ligands for the Human Serotonin Transporter Based on the Selective Serotonin Reuptake Inhibitor (S)-Citalopram
V Kumar, N Yarravarapu, DJ Lapinsky… - Journal of medicinal …, 2015 - ACS Publications
Three photoaffinity ligands (PALs) for the human serotonin transporter (hSERT) were
synthesized based on the selective serotonin reuptake inhibitor (SSRI),(S)-citalopram (1) …
synthesized based on the selective serotonin reuptake inhibitor (SSRI),(S)-citalopram (1) …