[HTML][HTML] A new look at cerebrospinal fluid circulation
T Brinker, E Stopa, J Morrison, P Klinge - Fluids and Barriers of the CNS, 2014 - Springer
According to the traditional understanding of cerebrospinal fluid (CSF) physiology, the
majority of CSF is produced by the choroid plexus, circulates through the ventricles, the …
majority of CSF is produced by the choroid plexus, circulates through the ventricles, the …
Glymphatic system disruption as a mediator of brain trauma and chronic traumatic encephalopathy
Traumatic brain injury (TBI) is an increasingly important issue among veterans, athletes and
the general public. Difficulties with sleep onset and maintenance are among the most …
the general public. Difficulties with sleep onset and maintenance are among the most …
[HTML][HTML] Neurovascular unit as a source of ischemic stroke biomarkers—limitations of experimental studies and perspectives for clinical application
A Steliga, P Kowiański, E Czuba, M Waśkow… - Translational stroke …, 2020 - Springer
Cerebral stroke, which is one of the most frequent causes of mortality and leading cause of
disability in developed countries, often leads to devastating and irreversible brain damage …
disability in developed countries, often leads to devastating and irreversible brain damage …
[HTML][HTML] Inhibition of aquaporin 4 decreases amyloid Aβ40 drainage around cerebral vessels
GC Rosu, B Catalin, TA Balseanu, M Laurentiu… - Molecular …, 2020 - Springer
Abstract Aquaporin-4 (AQP4) is located mainly in the astrocytic end-feet around cerebral
blood vessels and regulates ion and water homeostasis in the brain. While deletion of AQP4 …
blood vessels and regulates ion and water homeostasis in the brain. While deletion of AQP4 …
[HTML][HTML] Inhibition of aquaporin-4 improves the outcome of ischaemic stroke and modulates brain paravascular drainage pathways
Aquaporin-4 (AQP4) is the most abundant water channel in the brain, and its inhibition
before inducing focal ischemia, using the AQP4 inhibitor TGN-020, has been showed to …
before inducing focal ischemia, using the AQP4 inhibitor TGN-020, has been showed to …
[HTML][HTML] AQP1 and AQP4 contribution to cerebrospinal fluid homeostasis
JL Trillo-Contreras, JJ Toledo-Aral, M Echevarría… - Cells, 2019 - mdpi.com
Aquaporin 1 (AQP1), expressed in epithelial cells of the choroid plexus, and aquaporin 4
(AQP4) present in ependymal cells and glia limitants have been proposed to play a …
(AQP4) present in ependymal cells and glia limitants have been proposed to play a …
Research into the physiology of cerebrospinal fluid reaches a new horizon: intimate exchange between cerebrospinal fluid and interstitial fluid may contribute to …
M Matsumae, O Sato, A Hirayama… - Neurologia medico …, 2016 - jstage.jst.go.jp
Cerebrospinal fluid (CSF) plays an essential role in maintaining the homeostasis of the
central nervous system. The functions of CSF include:(1) buoyancy of the brain, spinal cord …
central nervous system. The functions of CSF include:(1) buoyancy of the brain, spinal cord …
Transmembrane water-efflux rate measured by magnetic resonance imaging as a biomarker of the expression of aquaporin-4 in gliomas
Y Jia, S Xu, G Han, B Wang, Z Wang, C Lan… - Nature Biomedical …, 2023 - nature.com
The water-selective channel protein aquaporin-4 (AQP4) contributes to the migration and
proliferation of gliomas, and to their resistance to therapy. Here we show, in glioma cell …
proliferation of gliomas, and to their resistance to therapy. Here we show, in glioma cell …
[HTML][HTML] Aquaporin-4 facilitator TGN-073 promotes interstitial fluid circulation within the blood–brain barrier:[: 17: O] H: 2: O JJVCPE MRI study
VJ Huber, H Igarashi, S Ueki, IL Kwee, T Nakada - Neuroreport, 2018 - journals.lww.com
The blood–brain barrier (BBB), which imposes significant water permeability restriction,
effectively isolates the brain from the systemic circulation. Seemingly paradoxical, the …
effectively isolates the brain from the systemic circulation. Seemingly paradoxical, the …
Brain water channel proteins in health and disease
O Benga, VJ Huber - Molecular aspects of medicine, 2012 - Elsevier
The aim of this article is to describe the roles of water channel proteins (WCPs) in brain
functionality. The fluid compartments of the brain, which include the brain parenchyma (with …
functionality. The fluid compartments of the brain, which include the brain parenchyma (with …