The molecular biology of FMRP: new insights into fragile X syndrome

JD Richter, X Zhao - Nature Reviews Neuroscience, 2021 - nature.com
Fragile X mental retardation protein (FMRP) is the product of the fragile X mental retardation
1 gene (FMR1), a gene that—when epigenetically inactivated by a triplet nucleotide repeat …

Developmental mechanisms underlying the evolution of human cortical circuits

P Vanderhaeghen, F Polleux - Nature Reviews Neuroscience, 2023 - nature.com
The brain of modern humans has evolved remarkable computational abilities that enable
higher cognitive functions. These capacities are tightly linked to an increase in the size and …

[HTML][HTML] Evolution of the human nervous system function, structure, and development

AMM Sousa, KA Meyer, G Santpere, FO Gulden… - Cell, 2017 - cell.com
The nervous system—in particular, the brain and its cognitive abilities—is among humans'
most distinctive and impressive attributes. How the nervous system has changed in the …

[HTML][HTML] The cellular and molecular landscapes of the developing human central nervous system

JC Silbereis, S Pochareddy, Y Zhu, M Li, N Sestan - Neuron, 2016 - cell.com
The human CNS follows a pattern of development typical of all mammals, but certain
neurodevelopmental features are highly derived. Building the human CNS requires the …

Molecular biomarkers for embryonic and adult neural stem cell and neurogenesis

J Zhang, J Jiao - BioMed research international, 2015 - Wiley Online Library
The procedure of neurogenesis has made numerous achievements in the past decades,
during which various molecular biomarkers have been emerging and have been broadly …

The road to precision psychiatry: translating genetics into disease mechanisms

MJ Gandal, V Leppa, H Won, NN Parikshak… - Nature …, 2016 - nature.com
Hundreds of genetic loci increasing risk for neuropsychiatric disorders have recently been
identified. This success, perhaps paradoxically, has posed challenges for therapeutic …

[图书][B] ¿ Cómo aprendemos?: Los cuatro pilares con los que la educación puede potenciar los talentos de nuestro cerebro

S Dehaene - 2019 - books.google.com
El cerebro humano es una máquina extraordinaria, capaz de transformarse a sí misma a
partir de la experiencia y de albergar talentos que nos vuelven únicos como especie …

Transcriptional co-regulation of neuronal migration and laminar identity in the neocortex

KY Kwan, N Šestan, ES Anton - Development, 2012 - journals.biologists.com
The cerebral neocortex is segregated into six horizontal layers, each containing unique
populations of molecularly and functionally distinct excitatory projection (pyramidal) neurons …

Exploring early human brain development with structural and physiological neuroimaging

L Vasung, EA Turk, SL Ferradal, J Sutin, JN Stout… - Neuroimage, 2019 - Elsevier
Early brain development, from the embryonic period to infancy, is characterized by rapid
structural and functional changes. These changes can be studied using structural and …

Hominini-specific regulation of CBLN2 increases prefrontal spinogenesis

M Shibata, K Pattabiraman, SK Muchnik, N Kaur… - Nature, 2021 - nature.com
The similarities and differences between nervous systems of various species result from
developmental constraints and specific adaptations,,–. Comparative analyses of the …