Recent advances in cancer immunotherapy—ranging from immune-checkpoint blockade
therapy to adoptive cellular therapy and vaccines—have revolutionized cancer treatment …

In addition to CD4+ T cells and neutralizing antibodies, CD8+ T cells contribute to protective
immune responses against SARS-CoV-2 in patients with coronavirus disease 2019 (COVID …

Summary Blocking PD-1/PD-L1 signaling transforms cancer therapy and is assumed to
unleash exhausted tumor-reactive CD8+ T cells in the tumor microenvironment (TME) …

The common view is that T lymphocytes activate telomerase to delay senescence. Here we
show that some T cells (primarily naïve and central memory cells) elongated telomeres by …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of vaccinated
individuals is increasingly common but rarely results in severe disease, likely due to the …

Human T cells coordinate adaptive immunity in diverse anatomic compartments through
production of cytokines and effector molecules, but it is unclear how tissue site influences T …

Memory T cell responses have been demonstrated in COVID-19 convalescents, but ex vivo
phenotypes of SARS-CoV-2-specific T cells have been unclear. We detected SARS-CoV-2 …

Progenitor-like CD8+ T cells mediate long-term immunity to chronic infection and cancer and
respond potently to immune checkpoint blockade. These cells share transcriptional …

Chimeric antigen receptor (CAR)-T-cell therapy for solid tumors is limited due to
heterogeneous target antigen expression and outgrowth of tumors lacking the antigen …

Throughout life, T cells coordinate multiple aspects of adaptive immunity, including
responses to pathogens, allergens, and tumors. In mouse models, the role of T cells is …