Cells use mitophagy to remove dysfunctional or excess mitochondria, frequently in response
to imposed stresses, such as hypoxia and nutrient deprivation. Mitochondrial cargo …

Mitophagy is a highly conserved cellular process that maintains the mitochondrial quantity
by eliminating dysfunctional or superfluous mitochondria through autophagy machinery. The …

BNIP3 and NIX are proteins related to the BH3-only family, which induce both cell death and
autophagy. Consistent with their ability to induce cell death, BNIP3 and NIX are implicated in …

Nix is a membrane‐anchored outer mitochondrial protein that induces mitophagy. While Nix
has an LC3‐interacting (LIR) motif that binds to ATG8 proteins, it also contains a minimal …

Adenoviruses have been characterized extensively since their initial description in the early
1950s (Hillemann & Werner, 1954; Rowe et al., 1953) and there is now a panoply of …

Many apoptotic signaling pathways are directed to mitochondria, where they initiate the
release of apoptogenic proteins and open the proposed mitochondrial permeability …

The rapid accumulation of knowledge on apoptosis regulation in the 1990s was followed by
the development of several experimental anticancer‐and anti‐ischaemia (stroke or …

It has been shown that oxygen deprivation results in apoptotic cell death, and that hypoxia
inducible factor 1 (HIF1) and the tumor suppressor p53 play key roles in this process …

BNIP3 (formerly NIP3) is a pro-apoptotic, mitochondrial protein classified in the Bcl-2 family
based on limited sequence homology to the Bcl-2 homology 3 (BH3) domain and COOH …

Autophagy, a pathway primarily relevant for cell survival, and apoptosis, a process invariably
leading to cell death, are the two main mechanisms of cellular self-destruction, which are …