The predominantly animal-centric approach of chemical safety assessment has increasingly
come under pressure. Society is questioning overall performance, sustainability, continued …

Advances in the biological sciences have led to an ongoing paradigm shift in toxicity testing
based on expanded application of high-throughput in vitro screening and in silico methods …

Abstract The US Environmental Protection Agency (EPA) is faced with the challenge of
efficiently and credibly evaluating chemical safety often with limited or no available toxicity …

Thousands of chemicals have been profiled by high-throughput screening programs such as
ToxCast and Tox21; these chemicals are tested in part because most of them have limited or …

Background: Laboratory and human studies raise concerns about endocrine disruption and
asthma resulting from exposure to chemicals in consumer products. Limited labeling or …

In vitro chemical safety testing methods offer the potential for efficient and economical tools
to provide relevant assessments of human health risk. To realize this potential, methods are …

Background: Endocrine disrupting chemicals (EDCs) are xenobiotics that mimic the
interaction of natural hormones and alter synthesis, transport, or metabolic pathways. The …

We demonstrate a computational network model that integrates 18 in vitro, high-throughput
screening assays measuring estrogen receptor (ER) binding, dimerization, chromatin …

Triclosan (TCS) is a broad-spectrum antimicrobial agent that has been added to personal
care products, including hand soaps and cosmetics, and impregnated in numerous different …

The field of toxicology is on the cusp of a major transformation in how the safety and hazard
of chemicals are evaluated for potential effects on human health and the environment …