The p53 pathway has been shown to mediate cellular stress responses; p53 can initiate
DNA repair, cell-cycle arrest, senescence and, importantly, apoptosis. These responses …

The normal functioning of p53 is a potent barrier to cancer. Tumour-associated mutations in
TP53, typically single nucleotide substitutions in the coding sequence, are a hallmark of …

Extensive studies have shown that p53 is important in tumour prevention. However, little is
known about its normal physiological function. Here we show that p53 is important in …

The tumor suppressor protein p53 plays an important role in maternal reproduction in mice
through transcriptional regulation of leukemia inhibitory factor (LIF), a cytokine crucial for …

The ability of p53 to regulate transcription is crucial for tumor suppression and implies that
inherited polymorphisms in functional p53-binding sites could influence cancer. Here, we …

MDM2 plays a key role in modulating p53 function. The MDM2 SNP309T> G promoter
polymorphism enhances Sp1 binding and has been linked to cancer risk and young age at …

Neuroendocrine tumors (NETs) comprise a group of rare tumors derived from the diffuse
neuroendocrine system or islet endocrine cells of the pancreas. The molecular mechanisms …

The p53 tumor suppressor pathway is central both in reducing cancer frequency in
vertebrates and in mediating the response of commonly used cancer therapies. This article …

The p53 family of genes (p53, p63, and p73) is conserved over evolutionary time scales.
Although the functions of p53 gene and its protein as a tumor suppressor have been firmly …

Tumor suppressor p53 is crucial for embryonic implantation through transcriptional up-
regulation of uterine leukemia inhibitory factor (LIF). This article reports that p53 and …