The Molecular Balancing Act of p16INK4a in Cancer and Aging

KM LaPak, CE Burd - Molecular Cancer Research, 2014 - AACR
Abstract p16INK4a, located on chromosome 9p21. 3, is lost among a cluster of neighboring
tumor suppressor genes. Although it is classically known for its capacity to inhibit cyclin …

Functional genomics of the CDKN2A/B locus in cardiovascular and metabolic disease: what have we learned from GWASs?

SA Hannou, K Wouters, R Paumelle, B Staels - Trends in Endocrinology & …, 2015 - cell.com
Genome-wide association studies (GWASs) provide an unprecedented opportunity to
examine, on a large scale, the association of common genetic variants with complex …

Rare deleterious mutations of HNRNP genes result in shared neurodevelopmental disorders

MA Gillentine, T Wang, K Hoekzema, J Rosenfeld… - Genome medicine, 2021 - Springer
Background With the increasing number of genomic sequencing studies, hundreds of genes
have been implicated in neurodevelopmental disorders (NDDs). The rate of gene discovery …

Hallmarks of cancer and AU‐rich elements

KSA Khabar - Wiley Interdisciplinary Reviews: RNA, 2017 - Wiley Online Library
Post‐transcriptional control of gene expression is aberrant in cancer cells. Sustained
stabilization and enhanced translation of specific mRNAs are features of tumor cells. AU …

Convergence of therapy-induced senescence (TIS) and EMT in multistep carcinogenesis: current opinions and emerging perspectives

MM Faheem, ND Seligson, SM Ahmad, RU Rasool… - Cell death …, 2020 - nature.com
Drug induced resistance is a widespread problem in the clinical management of cancer.
Cancer cells, when exposed to cytotoxic drugs, can reprogram their cellular machinery and …

The role of noncoding RNAs in the regulation of anoikis and anchorage-independent growth in cancer

HY Lee, SW Son, S Moeng, SY Choi… - International journal of …, 2021 - mdpi.com
Cancer is a global health concern, and the prognosis of patients with cancer is associated
with metastasis. Multistep processes are involved in cancer metastasis. Accumulating …

Physiological networks and disease functions of RNA‐binding protein AUF1

AE Moore, DM Chenette, LC Larkin… - Wiley Interdisciplinary …, 2014 - Wiley Online Library
Regulated messenger RNA (mRNA) decay is an essential mechanism that governs proper
control of gene expression. In fact, many of the most physiologically potent proteins are …

The cytokine IL-6 reactivates breast stromal fibroblasts through transcription factor STAT3-dependent up-regulation of the RNA-binding protein AUF1

SF Hendrayani, HH Al-Khalaf… - Journal of Biological …, 2014 - ASBMB
The development and spread of mammary carcinomas require synergetic interplay between
tumor cells and their microenvironment through paracrine secretions, which are still not well …

MicroRNA-141 and microRNA-146b-5p inhibit the prometastatic mesenchymal characteristics through the RNA-binding protein AUF1 targeting the transcription factor …

HH Al-Khalaf, A Aboussekhra - Journal of Biological Chemistry, 2014 - ASBMB
miR-141 and miR-146b-5p are two important tumor suppressor microRNAs, which control
several cancer-related genes and processes. In the present report, we have shown that …

NFκB (RelA) mediates transactivation of hnRNPD in oral cancer cells

V Kumar, A Kumar, M Kumar, MR Lone, D Mishra… - Scientific Reports, 2022 - nature.com
Abstract Heterogeneous Ribonucleoprotein D (hnRNPD) is an RNA binding protein involved
in post-transcriptional regulation of multiple mediators of carcinogenesis. We previously …