The Molecular Balancing Act of p16INK4a in Cancer and Aging
KM LaPak, CE Burd - Molecular Cancer Research, 2014 - AACR
Abstract p16INK4a, located on chromosome 9p21. 3, is lost among a cluster of neighboring
tumor suppressor genes. Although it is classically known for its capacity to inhibit cyclin …
tumor suppressor genes. Although it is classically known for its capacity to inhibit cyclin …
Functional genomics of the CDKN2A/B locus in cardiovascular and metabolic disease: what have we learned from GWASs?
Genome-wide association studies (GWASs) provide an unprecedented opportunity to
examine, on a large scale, the association of common genetic variants with complex …
examine, on a large scale, the association of common genetic variants with complex …
Rare deleterious mutations of HNRNP genes result in shared neurodevelopmental disorders
Background With the increasing number of genomic sequencing studies, hundreds of genes
have been implicated in neurodevelopmental disorders (NDDs). The rate of gene discovery …
have been implicated in neurodevelopmental disorders (NDDs). The rate of gene discovery …
Hallmarks of cancer and AU‐rich elements
KSA Khabar - Wiley Interdisciplinary Reviews: RNA, 2017 - Wiley Online Library
Post‐transcriptional control of gene expression is aberrant in cancer cells. Sustained
stabilization and enhanced translation of specific mRNAs are features of tumor cells. AU …
stabilization and enhanced translation of specific mRNAs are features of tumor cells. AU …
Convergence of therapy-induced senescence (TIS) and EMT in multistep carcinogenesis: current opinions and emerging perspectives
MM Faheem, ND Seligson, SM Ahmad, RU Rasool… - Cell death …, 2020 - nature.com
Drug induced resistance is a widespread problem in the clinical management of cancer.
Cancer cells, when exposed to cytotoxic drugs, can reprogram their cellular machinery and …
Cancer cells, when exposed to cytotoxic drugs, can reprogram their cellular machinery and …
The role of noncoding RNAs in the regulation of anoikis and anchorage-independent growth in cancer
HY Lee, SW Son, S Moeng, SY Choi… - International journal of …, 2021 - mdpi.com
Cancer is a global health concern, and the prognosis of patients with cancer is associated
with metastasis. Multistep processes are involved in cancer metastasis. Accumulating …
with metastasis. Multistep processes are involved in cancer metastasis. Accumulating …
Physiological networks and disease functions of RNA‐binding protein AUF1
AE Moore, DM Chenette, LC Larkin… - Wiley Interdisciplinary …, 2014 - Wiley Online Library
Regulated messenger RNA (mRNA) decay is an essential mechanism that governs proper
control of gene expression. In fact, many of the most physiologically potent proteins are …
control of gene expression. In fact, many of the most physiologically potent proteins are …
The cytokine IL-6 reactivates breast stromal fibroblasts through transcription factor STAT3-dependent up-regulation of the RNA-binding protein AUF1
SF Hendrayani, HH Al-Khalaf… - Journal of Biological …, 2014 - ASBMB
The development and spread of mammary carcinomas require synergetic interplay between
tumor cells and their microenvironment through paracrine secretions, which are still not well …
tumor cells and their microenvironment through paracrine secretions, which are still not well …
MicroRNA-141 and microRNA-146b-5p inhibit the prometastatic mesenchymal characteristics through the RNA-binding protein AUF1 targeting the transcription factor …
HH Al-Khalaf, A Aboussekhra - Journal of Biological Chemistry, 2014 - ASBMB
miR-141 and miR-146b-5p are two important tumor suppressor microRNAs, which control
several cancer-related genes and processes. In the present report, we have shown that …
several cancer-related genes and processes. In the present report, we have shown that …
NFκB (RelA) mediates transactivation of hnRNPD in oral cancer cells
Abstract Heterogeneous Ribonucleoprotein D (hnRNPD) is an RNA binding protein involved
in post-transcriptional regulation of multiple mediators of carcinogenesis. We previously …
in post-transcriptional regulation of multiple mediators of carcinogenesis. We previously …