Mitochondria play a major role in ROS production and defense during their life cycle. The
transcriptional activator PGC-1α is a key player in the homeostasis of energy metabolism …

In response to the energy demand triggered by developmental signals and environmental
stressors, the cells launch the mitochondrial biogenesis process. This is a self‐renewal …

Background: Diabetes mellitus exacerbates myocardial ischemia/reperfusion (MI/R) injury
by incompletely understood mechanisms. Adipocyte dysfunction contributes to remote organ …

MicroRNAs (miRNAs) are small non-coding single-stranded RNAs that are integral to a wide
range of cellular processes mainly through the regulation of translation and mRNA stability …

Despite decades of research in the field of human reproduction, the mechanisms
responsible for human parturition still remain elusive. The objective of this study was to …

Non-alcoholic fatty liver disease (NAFLD) is the number one chronic liver disease worldwide
and is estimated to affect nearly 40% of obese youth and up to 10% of the general pediatric …

Age-related macular degeneration (AMD) is an ever-increasing, insidious disease which
reduces the quality of life of millions of elderly people around the world. AMD is …

The heart is a highly energy-dependent organ, and most of its energy is provided by
mitochondrial oxidative phosphorylation. Therefore, maintaining a well-functioning …

Acute pancreatitis (AP) remains a significant clinical challenge. Mitochondrial dysfunction
contributes significantly to the pathogenesis of AP. Milk fat globule EGF factor 8 (MFG‐E8) is …

Oxidative stress-induced autophagy dysfunction is involved in the pathogenesis of
intervertebral disc degeneration (IVDD). MicroRNAs (miRNAs) not only have been regarded …