Reactive oxygen species (ROS), superoxide anion and hydrogen peroxide, are generated
as byproducts of oxidative phosphorylation in the mitochondria or via cell signaling-induced …

Meiosis is the basis of sexual reproduction. In female mammals, meiosis of oocytes starts
before birth and sustains at the dictyate stage of meiotic prophase I before gonadotropins …

Acetylation of lysine 16 on histone H4 (H4K16ac) is catalyzed by histone acetyltransferase
KAT8 and can prevent chromatin compaction in vitro. Although extensively studied in …

Epigenetic integrity is critical for many eukaryotic cellular processes. An important question
is how different epigenetic regulators control development and influence disease. Lysine …

Self-renewing embryonic stem cells (ESCs) respond to environmental cues by exiting
pluripotency or entering a quiescent state. The molecular basis underlying this fate choice …

Activation of hepatic stellate cells (HSC) is a hallmark event in liver fibrosis. Accumulation of
reactive oxygen species (ROS) serves as a driving force for HSC activation. The regulatory …

Abnormal trophoblast self-renewal and differentiation during early gestation is the major
cause of miscarriage, yet the underlying regulatory mechanisms remain elusive. Here, we …

Aims: The mechanisms coordinating maturation with an environment-driven metabolic shift,
a critical step in determining the developmental potential of human in vitro maturation (IVM) …

Abstract Histone deacetylase 1 (HDAC1) is known to participate in the molecular etiology of
polycystic ovary syndrome (PCOS). However, its role in granulosa cell (GC) pyroptosis …

There are more than 2300 genes that are predominantly expressed in mouse testes. The
role of hundreds of these genes has been studied in mouse spermatogenesis but still there …