RNA-binding proteins in cancer: old players and new actors
RNA-binding proteins (RBPs) are key players in post-transcriptional events. The
combination of versatility of their RNA-binding domains with structural flexibility enables …
combination of versatility of their RNA-binding domains with structural flexibility enables …
The LIN28/let-7 pathway in cancer
Among all tumor suppressor microRNAs, reduced let-7 expression occurs most frequently in
cancer and typically correlates with poor prognosis. Activation of either LIN28A or LIN28B …
cancer and typically correlates with poor prognosis. Activation of either LIN28A or LIN28B …
Epigenetic alterations in colorectal cancer: emerging biomarkers
Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. One of the
fundamental processes driving the initiation and progression of CRC is the accumulation of …
fundamental processes driving the initiation and progression of CRC is the accumulation of …
Cancer the 'RBP'eutics–RNA-binding proteins as therapeutic targets for cancer
RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes,
including splicing, cleavage and polyadenylation, transport, translation and degradation of …
including splicing, cleavage and polyadenylation, transport, translation and degradation of …
Polyamines and related signaling pathways in cancer
J Li, Y Meng, X Wu, Y Sun - Cancer cell international, 2020 - Springer
Polyamines are aliphatic compounds with more than two amino groups that play various
important roles in human cells. In cancer, polyamine metabolism dysfunction often occurs …
important roles in human cells. In cancer, polyamine metabolism dysfunction often occurs …
Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma
Poor prognosis in neuroblastoma is associated with genetic amplification of MYCN. MYCN
is itself a target of let-7, a tumour suppressor family of microRNAs implicated in numerous …
is itself a target of let-7, a tumour suppressor family of microRNAs implicated in numerous …
MicroRNAs in the etiology of colorectal cancer: pathways and clinical implications
AM Strubberg, BB Madison - Disease models & …, 2017 - journals.biologists.com
MicroRNAs (miRNAs) are small single-stranded RNAs that repress mRNA translation and
trigger mRNA degradation. Of the∼ 1900 miRNA-encoding genes present in the human …
trigger mRNA degradation. Of the∼ 1900 miRNA-encoding genes present in the human …
RNA binding proteins in intestinal epithelial biology and colorectal cancer
P Chatterji, AK Rustgi - Trends in molecular medicine, 2018 - cell.com
The intestinal epithelium is highly proliferative and consists of crypt invaginations that house
stem cells and villus projections with differentiated cells. There exists a dynamic equilibrium …
stem cells and villus projections with differentiated cells. There exists a dynamic equilibrium …
Small-molecule inhibitors disrupt let-7 oligouridylation and release the selective blockade of let-7 processing by LIN28
LIN28 is an RNA-binding protein that regulates the maturation of the let-7 family of
microRNAs by bipartite interactions with let-7 precursors through its two distinct cold shock …
microRNAs by bipartite interactions with let-7 precursors through its two distinct cold shock …
Lin28 signaling supports mammalian PNS and CNS axon regeneration
RNA-binding proteins Lin28a/b regulate cellular growth and tissue regeneration. Here, we
investigated the role of Lin28 in the control of axon regeneration in postmitotic neurons. We …
investigated the role of Lin28 in the control of axon regeneration in postmitotic neurons. We …