Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …

It has recently been demonstrated that the genes controlling the epigenetic programmes that
are required for maintaining chromatin structure and cell identity include genes that drive …

Lysine methylation is one of the most prominent histone posttranslational modifications that
regulate chromatin structure. Changes in histone lysine methylation status have been …

The pharmacological inhibition of general transcriptional regulators has the potential to
block growth through targeting multiple tumorigenic signalling pathways simultaneously …

Hypoxia (low O 2) is an essential microenvironmental driver of phenotypic diversity in
human solid cancers. Hypoxic cancer cells hijack evolutionarily conserved, O 2-sensitive …

The occurrence of cancer entails a series of genetic mutations that favor uncontrollable
tumor growth. It is believed that various factors collectively contribute to cancer, and there is …

The Notch signaling pathway acts in both physiological and pathological conditions,
including embryonic development and tumorigenesis. In cancer progression, diverse …

Abstract The KDM4 subfamily H3K9 histone demethylases are epigenetic regulators that
control chromatin structure and gene expression by demethylating histone H3K9, H3K36 …

Estrogens and estrogen receptors (ERs) regulate metabolism in both normal physiology and
in disease. The metabolic characteristics of intrinsic breast cancer subtypes change based …

Significance: Chronic obstructive pulmonary disease (COPD) is predominantly a tobacco
smoke-triggered disease with features of chronic low-grade systemic inflammation and …