Positron emission tomography (PET) with radiotracers that bind to synaptic vesicle
glycoprotein 2 A (SV2A) enables quantification of synaptic density in the living human brain …

There is extensive synaptic loss from frontotemporal lobar degeneration, in preclinical
models and human in vivo and post mortem studies. Understanding the consequences of …

Background Synaptic loss is characteristic of many neurodegenerative diseases; it occurs
early and is strongly related to functional deficits. Objective In this longitudinal observational …

Progressive supranuclear palsy (PSP) is a neurodegenerative disorder characterized by
early postural instability and falls, oculomotor dysfunction (vertical supranuclear gaze palsy) …

Alzheimer's disease affects our cognitive neurophysiology by loss of neurones, synapses
and neurotransmitters. An improved mechanistic understanding of the human disease will …

Synaptic terminal density is thought to influence cognitive function and neural activity, yet its
role in cognition has not been explored in healthy humans. We examined these …

This study assesses the reliability of resting-state dynamic causal modelling (DCM) of
magneto-electroencephalography under conductance-based canonical microcircuit models …

The syndromes associated with frontotemporal dementia are heterogeneous in their
presentation and progression, with variable correlation between clinical phenotype and …