Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

BR Stockwell - Cell, 2022 - cell.com
Ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, was identified
as a distinct phenomenon and named a decade ago. Ferroptosis has been implicated in a …

Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney

H Bayır, SJ Dixon, YY Tyurina, JA Kellum… - Nature Reviews …, 2023 - nature.com
Ferroptosis is a mechanism of regulated necrotic cell death characterized by iron-
dependent, lipid peroxidation-driven membrane destruction that can be inhibited by …

Diverse biological functions of vitamin K: from coagulation to ferroptosis

E Mishima, A Wahida, T Seibt, M Conrad - Nature metabolism, 2023 - nature.com
Vitamin K is essential for several physiological processes, such as blood coagulation, in
which it serves as a cofactor for the conversion of peptide-bound glutamate to γ …

[HTML][HTML] Ferroptosis is the key cellular process mediating Bisphenol A responses in Chlamydomonas and a promising target for enhancing microalgae-based …

M Carbó, P Chaturvedi, A Álvarez… - Journal of Hazardous …, 2023 - Elsevier
Microplastics are one of the major pollutants in aquatic environments. Among their
components, Bisphenol A (BPA) is one of the most abundant and dangerous, leading to …

[HTML][HTML] The glutathione system: a journey from cyanobacteria to higher eukaryotes

C Cassier-Chauvat, F Marceau, S Farci, S Ouchane… - Antioxidants, 2023 - mdpi.com
From bacteria to plants and humans, the glutathione system plays a pleiotropic role in cell
defense against metabolic, oxidative and metal stresses. Glutathione (GSH), the γ-L …

Resveratrol alleviated 5-FU-induced cardiotoxicity by attenuating GPX4 dependent ferroptosis

D Li, C Song, J Zhang, X Zhao - The Journal of Nutritional Biochemistry, 2023 - Elsevier
The clinical use of 5-fluorouracil (5-FU), a potent antitumor agent, was limited by severe
cardiotoxic effects. The present study was aimed to investigate the protective effects of …

[HTML][HTML] Targeting of HBP1/TIMP3 axis as a novel strategy against breast cancer

Y Zhou, T Zhang, S Wang, R Yang, Z Jiao, K Lu… - Pharmacological …, 2023 - Elsevier
Malignant proliferation and metastasis are the main causes of breast cancer death. The
transcription factor high mobility group (HMG) box-containing protein 1 (HBP1) is an …

Heat stress in plants: sensing, signalling, and ferroptosis

AM Distéfano, V Bauer, M Cascallares… - Journal of …, 2024 - academic.oup.com
In the current context of global warming, high temperature events are becoming more
frequent and intense in many places around the world. In this context, understanding how …

Ferroptosis in plants: regulation of lipid peroxidation and redox status

AM Distéfano, GA López, V Bauer… - Biochemical …, 2022 - portlandpress.com
Regulated cell death (RCD) is an essential process that plays key roles along the plant life
cycle. Unlike accidental cell death, which is an uncontrolled biological process, RCD …

Role of amyloid beta (25− 35) neurotoxicity in the ferroptosis and necroptosis as modalities of regulated cell death in Alzheimer's disease

S Naderi, F Khodagholi, HG Pourbadie, N Naderi… - Neurotoxicology, 2023 - Elsevier
Neuronal cell death as a prominent pathological feature contributes to cognitive decline and
memory loss in Alzheimer's disease. We investigated the role of two forms of cell death …