The gut microbiome and HIV-1 pathogenesis: a two-way street

SM Dillon, DN Frank, CC Wilson - Aids, 2016 - journals.lww.com
HIV-1 infection is associated with substantial damage to the gastrointestinal tract resulting in
structural impairment of the epithelial barrier and a disruption of intestinal homeostasis. The …

Altered gut microbiome composition in HIV infection: causes, effects and potential intervention

A Bandera, I De Benedetto, G Bozzi… - Current opinion in HIV …, 2018 - journals.lww.com
Studying the human host–microbiota interaction suggests that the consequences of HIV
infection on microbial composition can influence immune status in HIV patients. ART …

Low abundance of colonic butyrate-producing bacteria in HIV infection is associated with microbial translocation and immune activation

SM Dillon, J Kibbie, EJ Lee, K Guo, ML Santiago… - Aids, 2017 - journals.lww.com
Objective: Gut microbial translocation is a major driving force behind chronic immune
activation during HIV-1 infection. HIV-1-related intestinal dysbiosis, including increases in …

HIV persists in CCR6+ CD4+ T cells from colon and blood during antiretroviral therapy

A Gosselin, TRW Salinas, D Planas, VS Wacleche… - Aids, 2017 - journals.lww.com
Objectives: The objective of this article is to investigate the contribution of colon and blood
CD4+ T-cell subsets expressing the chemokine receptor CCR6 to HIV persistence during …

The Th17 lineage: from barrier surfaces homeostasis to autoimmunity, cancer, and HIV-1 pathogenesis

VS Wacleche, A Landay, JP Routy, P Ancuta - Viruses, 2017 - mdpi.com
The T helper 17 (Th17) cells represent a subset of CD4+ T-cells with unique effector
functions, developmental plasticity, and stem-cell features. Th17 cells bridge innate and …

Probiotic supplementation promotes a reduction in T‐cell activation, an increase in Th17 frequencies, and a recovery of intestinal epithelium integrity and …

G d'Ettorre, G Rossi, C Scagnolari… - Immunity …, 2017 - Wiley Online Library
Introduction HIV infection is characterized by a persistent immune activation associated to a
compromised gut barrier immunity and alterations in the profile of the fecal flora linked with …

Gut dysbiosis associates with cytokine production capacity in viral-suppressed people living with HIV

Y Zhang, S Andreu-Sánchez, N Vadaq… - Frontiers in Cellular …, 2023 - frontiersin.org
Background People living with human immunodeficiency virus (PLHIV) are exposed to
chronic immune dysregulation, even when virus replication is suppressed by antiretroviral …

Fecal microbiota composition drives immune activation in HIV-infected individuals

CP Neff, O Krueger, K Xiong, S Arif, N Nusbacher… - …, 2018 - thelancet.com
The inflammatory properties of the enteric microbiota of Human Immunodeficiency Virus
(HIV)-infected individuals are of considerable interest because of strong evidence that …

[HTML][HTML] HIV-1 selectively targets gut-homing CCR6+ CD4+ T cells via mTOR-dependent mechanisms

D Planas, Y Zhang, P Monteiro, JP Goulet, A Gosselin… - JCI insight, 2017 - ncbi.nlm.nih.gov
Gut-associated lymphoid tissues are enriched in CCR6+ Th17-polarized CD4+ T cells that
contribute to HIV-1 persistence during antiretroviral therapy (ART). This raises the need for …

Butyrate directly decreases human gut lamina propria CD4 T cell function through histone deacetylase (HDAC) inhibition and GPR43 signaling

JJ Kibbie, SM Dillon, TA Thompson, CM Purba… - Immunobiology, 2021 - Elsevier
An important function of the gut microbiome is the fermentation of non-digestible dietary
fibers into short chain fatty acids (SCFAs). The three primary SCFAs: acetate, propionate …