Functional long non-coding RNAs evolve from junk transcripts
AF Palazzo, EV Koonin - Cell, 2020 - cell.com
Transcriptome studies reveal pervasive transcription of complex genomes, such as those of
mammals. Despite popular arguments for functionality of most, if not all, of these transcripts …
mammals. Despite popular arguments for functionality of most, if not all, of these transcripts …
Emerging and evolving concepts in gene essentiality
Gene essentiality is a founding concept of genetics with important implications in both
fundamental and applied research. Multiple screens have been performed over the years in …
fundamental and applied research. Multiple screens have been performed over the years in …
Comparative genomics of the major parasitic worms
Nature genetics, 2019 - nature.com
Parasitic nematodes (roundworms) and platyhelminths (flatworms) cause debilitating
chronic infections of humans and animals, decimate crop production and are a major …
chronic infections of humans and animals, decimate crop production and are a major …
Enhancer evolution across 20 mammalian species
The mammalian radiation has corresponded with rapid changes in noncoding regions of the
genome, but we lack a comprehensive understanding of regulatory evolution in mammals …
genome, but we lack a comprehensive understanding of regulatory evolution in mammals …
The bioenergetic costs of a gene
M Lynch, GK Marinov - … of the National Academy of Sciences, 2015 - National Acad Sciences
An enduring mystery of evolutionary genomics concerns the mechanisms responsible for
lineage-specific expansions of genome size in eukaryotes, especially in multicellular …
lineage-specific expansions of genome size in eukaryotes, especially in multicellular …
Dynamics of genome size evolution in birds and mammals
A Kapusta, A Suh, C Feschotte - Proceedings of the …, 2017 - National Acad Sciences
Genome size in mammals and birds shows remarkably little interspecific variation compared
with other taxa. However, genome sequencing has revealed that many mammal and bird …
with other taxa. However, genome sequencing has revealed that many mammal and bird …
Biochemistry and evolution of anaerobic energy metabolism in eukaryotes
M Müller, M Mentel, JJ van Hellemond… - Microbiology and …, 2012 - Am Soc Microbiol
Major insights into the phylogenetic distribution, biochemistry, and evolutionary significance
of organelles involved in ATP synthesis (energy metabolism) in eukaryotes that thrive in …
of organelles involved in ATP synthesis (energy metabolism) in eukaryotes that thrive in …
Patterns and evolutionary consequences of pleiotropy
J Zhang - Annual Review of Ecology, Evolution, and Systematics, 2023 - annualreviews.org
Pleiotropy refers to the phenomenon of one gene or one mutation affecting multiple
phenotypic traits. While the concept of pleiotropy is as old as Mendelian genetics, functional …
phenotypic traits. While the concept of pleiotropy is as old as Mendelian genetics, functional …
Is junk DNA bunk? A critique of ENCODE
WF Doolittle - Proceedings of the National Academy of …, 2013 - National Acad Sciences
Do data from the Encyclopedia Of DNA Elements (ENCODE) project render the notion of
junk DNA obsolete? Here, I review older arguments for junk grounded in the C-value …
junk DNA obsolete? Here, I review older arguments for junk grounded in the C-value …
Genomic rearrangements and the evolution of clusters of locally adaptive loci
S Yeaman - Proceedings of the National Academy of …, 2013 - National Acad Sciences
Numerous studies of ecological genetics have found that alleles contributing to local
adaptation sometimes cluster together, forming “genomic islands of divergence.” Divergence …
adaptation sometimes cluster together, forming “genomic islands of divergence.” Divergence …