Transcriptome studies reveal pervasive transcription of complex genomes, such as those of
mammals. Despite popular arguments for functionality of most, if not all, of these transcripts …

Gene essentiality is a founding concept of genetics with important implications in both
fundamental and applied research. Multiple screens have been performed over the years in …

Parasitic nematodes (roundworms) and platyhelminths (flatworms) cause debilitating
chronic infections of humans and animals, decimate crop production and are a major …

The mammalian radiation has corresponded with rapid changes in noncoding regions of the
genome, but we lack a comprehensive understanding of regulatory evolution in mammals …

An enduring mystery of evolutionary genomics concerns the mechanisms responsible for
lineage-specific expansions of genome size in eukaryotes, especially in multicellular …

Genome size in mammals and birds shows remarkably little interspecific variation compared
with other taxa. However, genome sequencing has revealed that many mammal and bird …

Major insights into the phylogenetic distribution, biochemistry, and evolutionary significance
of organelles involved in ATP synthesis (energy metabolism) in eukaryotes that thrive in …

Pleiotropy refers to the phenomenon of one gene or one mutation affecting multiple
phenotypic traits. While the concept of pleiotropy is as old as Mendelian genetics, functional …

Do data from the Encyclopedia Of DNA Elements (ENCODE) project render the notion of
junk DNA obsolete? Here, I review older arguments for junk grounded in the C-value …

Numerous studies of ecological genetics have found that alleles contributing to local
adaptation sometimes cluster together, forming “genomic islands of divergence.” Divergence …