Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from
anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag …

Over the past three decades, an intricate interaction between immune activation, release of
pro-inflammatory cytokines and changes in brain circuits related to mood and behavior has …

Cytokines, signaling proteins produced by a variety of cell types, are essential for the
development and functioning of both innate and adaptive immune response. Cytokine gene …

Background Alzheimer's disease (AD) involves increased accumulation of amyloid-β (Aβ)
plaques and neurofibrillary tangles as well as neuronal loss in various regions of the …

IL-18 is a proinflammatory and immune regulatory cytokine, member of the IL-1 family. IL-18
was initially identified as an IFN-γ-inducing factor in T and NK cells, involved in Th1 …

To cite this article: Ben‐Shoshan M, Clarke AE. Anaphylaxis: past, present and future.
Allergy 2011; 66: 1–14. Abstract Anaphylaxis is a clinical emergency, and recent reports …

In 1999, Genes and Immunity published a systematic review and on-line database of
cytokine gene polymorphism in human disease, 1 and in 2001 a supplement to the review …

Interleukins (ILs)—which are important members of cytokines—consist of a vast group of
molecules, including a wide range of immune mediators that contribute to the immunological …

In addition to their well-established role (s) in the pathogenesis of gastrointestinal (GI)-
related inflammatory disorders, including inflammatory bowel disease (IBD) and …

Background—Interleukin (IL)-18 plays a key role in atherosclerosis and its complications.
The present study investigated the genetic variability of 4 genes of the IL-18 system—IL18 …