Accumulating evidence from studies in humans and animal models has elucidated that gut
microbiota, acting as a complex ecosystem, contributes critically to colorectal cancer (CRC) …

Polyamines are small, abundant, aliphatic molecules present in all mammalian cells. Within
the context of the cell, they play a myriad of roles, from modulating nucleic acid conformation …

PURPOSE Long-term survival in high-risk neuroblastoma (HRNB) is approximately 50%,
with mortality primarily driven by relapse. Eflornithine (DFMO) to reduce risk of relapse after …

Abdominal aortic aneurysm (AAA) is a common vascular disease associated with significant
phenotypic alterations in vascular smooth muscle cells (VSMCs). Gasdermin D (GSDMD) is …

The study of metabolism has provided remarkable information about the biological basis
and therapeutic weaknesses of cancer cells. Classic biochemistry established the …

Since the demonstration of its involvement in cell proliferation, the eukaryotic initiation factor
5A (eIF5A) has been studied principally in relation to the development and progression of …

Polyamines are essential biomolecules for normal cellular metabolism in humans. The roles
of polyamines in cancer development have been widely discussed in recent years. Among …

The success of innovative drugs depends on an interdisciplinary and holistic approach to
their design and development. The supramolecular architecture of living systems is …

As obligate intracellular parasites, viruses rely on host cells for the building blocks of
progeny viruses. Metabolites such as amino acids, nucleotides, and lipids are central to viral …

Spermidine, as a natural component from polyamine members, is originally isolated from
semen and also existed in many natural plants, and can be responsible for cell growth and …