Astrocytes contribute to the complex cellular pathology of Alzheimer's disease (AD).
Neurons and astrocytes function in close collaboration through neurotransmitter recycling …

Glucose is the long-established, obligatory fuel for brain that fulfills many critical functions,
including ATP production, oxidative stress management, and synthesis of neurotransmitters …

Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

Lactate in the brain has long been associated with ischaemia; however, more recent
evidence shows that it can be found there under physiological conditions. In the brain …

In the brain, increases in neural activity drive changes in local blood flow via neurovascular
coupling. The common explanation for increased blood flow (known as functional …

Neurons have more extended and complex shapes than other cells and consequently face a
greater challenge in distributing and maintaining mitochondria throughout their arbors …

Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …

In the last decade, much attention has been devoted to the effects of nutrient-related signals
on brain development and cognitive functions. A turning point was the discovery that brain …

Brains at rest generate dynamical activity that is highly structured in space and time. We
suggest that spontaneous activity, as in rest or dreaming, underlies top-down dynamics of …

The mammalian brain depends upon glucose as its main source of energy, and tight
regulation of glucose metabolism is critical for brain physiology. Consistent with its critical …