The ability of cells to deal with different types of stressful situations in a precise and
coordinated manner is key for survival and involves various signalling networks. Over the …

The majority of breast cancers express the estrogen receptor (ERα) and agents targeting this
pathway represent the main treatment modality. Endocrine therapy has proven successful in …

Metastasis has been considered as the terminal step of tumor progression. However, recent
genomic studies suggest that many metastases are initiated by further spread of other …

Continuous detection of raised intraocular pressure (IOP) could benefit the monitoring of
patients with glaucoma. Current contact lenses with embedded sensors for measuring IOP …

Cancer arises from a multitude of disorders resulting in loss of differentiation and a stem cell-
like phenotype characterized by uncontrolled growth. Polycomb Group (PcG) proteins are …

Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is
overexpressed in diverse carcinomas, including breast cancer. However, the molecular …

Abstract Triple-Negative Breast Cancer (TNBC) has a poor prognosis and adverse clinical
outcomes among all breast cancer subtypes as there is no available targeted therapy …

The p38 family is a highly evolutionarily conserved group of mitogen-activated protein
kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all …

Immune checkpoint inhibitors (ICIs) have demonstrated to be highly efficient in treating solid
tumors; however, many patients have limited benefits in terms of response and survival. This …

Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of polycomb repressive
complex 2 (PRC2). Dysregulation of EZH2 causes alteration of gene expression and …