Plant-based natural products for the discovery and development of novel anthelmintics against nematodes

M Liu, SK Panda, W Luyten - Biomolecules, 2020 - mdpi.com
Intestinal parasitic nematodes infect approximately two billion people worldwide. In the
absence of vaccines for human intestinal nematodes, control of infections currently relies …

An appraisal of natural products active against parasitic nematodes of animals

JF Garcia-Bustos, BE Sleebs, RB Gasser - Parasites & Vectors, 2019 - Springer
Here, the scientific and patent literature on the activities of purified natural compounds has
been reviewed, with the aim of assessing their suitability as anthelmintic drug discovery …

Therapeutic applications of natural products in herbal medicines, biodiscovery programs, and biomedicine

P Wangchuk - Journal of Biologically Active Products from Nature, 2018 - Taylor & Francis
Natural products had been one of the important sources of remedial agents for thousands of
years. From the data presented in this review, the utilization of biologically active natural …

Natural-product-based solutions for tropical infectious diseases

O Adegboye, MA Field, A Kupz, S Pai… - Clinical microbiology …, 2021 - Am Soc Microbiol
About half of the world's population and 80% of the world's biodiversity can be found in the
tropics. Many diseases are specific to the tropics, with at least 41 diseases caused by …

[HTML][HTML] An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes

FA Partridge, AE Brown, SD Buckingham… - International Journal for …, 2018 - Elsevier
Parasitic nematodes infect hundreds of millions of people and farmed livestock. Further,
plant parasitic nematodes result in major crop damage. The pipeline of therapeutic …

Natural products for infectious microbes and diseases: an overview of sources, compounds, and chemical diversities

L Luo, J Yang, C Wang, J Wu, Y Li, X Zhang… - Science China Life …, 2022 - Springer
Abstract As coronavirus disease 2019 (COVID-19) threatens human health globally,
infectious disorders have become one of the most challenging problem for the medical …

Natural products as anthelmintics: safeguarding animal health

AA Salim, MS Butler, MAT Blaskovich… - Natural Product …, 2023 - pubs.rsc.org
Covering literature to December 2022 This review provides a comprehensive account of all
natural products (500 compounds, including 17 semi-synthetic derivatives) described in the …

Therapeutic administration of Luteolin protects against Escherichia coli-derived Lipopolysaccharide-triggered inflammatory response and oxidative injury

A Shaukat, SA Rajput, M Ali, R Shukat, S Hanif… - Acta Tropica, 2024 - Elsevier
Endometritis reduces reproductive effectiveness and leads to significant financial losses in
the dairy sector. Luteolin is a natural phyto-flavonoid compound with many biological …

Drug discovery technologies: Caenorhabditis elegans as a model for anthelmintic therapeutics

D Sepúlveda‐Crespo, RM Reguera… - Medicinal research …, 2020 - Wiley Online Library
Helminthiasis is one of the gravest problems worldwide. There is a growing concern on less
available anthelmintics and the emergence of resistance creating a major threat to human …

Metabolomic profiling of the excretory–secretory products of hookworm and whipworm

P Wangchuk, K Kouremenos, RM Eichenberger… - Metabolomics, 2019 - Springer
Introduction Soil-transmitted helminths infect billions of people, livestock and companion
animals worldwide, and chronic infections with these nematodes represent a major health …