Since the 1990s, ionotropic glutamate receptors have served as an outstanding target for
drug discovery research aimed at the discovery of new neurotherapeutic agents. With the …

Aryl transfer reactions from arenediazonium salts have started to make their impact in
chemical biology with initial forays in the arena of arylative modifications and bio …

A manganese dioxide (MnO2)–methanesulfonic acid (CH3SO3H) oxidation system has
been developed to efficiently promote direct coupling of benzylic ethers and carbamates …

Bioisosterism of α‐amino acids is often accomplished by replacing the α‐carboxylate with
one of the many known carboxylic acid bioisosteres. However, bioisosterism of the whole α …

Trying to meet the multitarget-directed ligands strategy, a series of previously described aryl-
substituted phenylalanine derivatives, reported as competitive antagonists of α-amino-3 …

Herein we describe the first structure–activity relationship study of the broad-range iGluR
antagonist (2 S, 3 R)-3-(3-carboxyphenyl) pyrrolidine-2-carboxylic acid (1) by exploring the …

The critical role of α1-glycine receptor (α1-GLYRs) in pathological conditions such as
epilepsy is well known. In the present study, structure-activity relations for a series of …

Bromination of the polycyclic oxetane 2, 4-oxytwistane (rac-(1 R, 3 S, 4 R, 7 S, 9 R, 11 S)-2-
oxatetracyclo [5.3. 1.03, 11.04, 9] undecane) was undertaken in order to form 2, 4 …

Continued efforts into the discovery of ligands that target ionotropic glutamate receptors
(iGluRs) are important for studies of the physiological roles of the various iGluR subtypes as …

The benzylic positions of the phthalan and isochroman derivatives (1) as benzene-fused
cyclic ethers effectively underwent gold-catalyzed direct azidation using trimethylsilylazide …