Antibiotics are recognized widely for their benefits when used appropriately. However, they
are often used inappropriately despite the importance of responsible use within good clinical …

Immunocompromised patients account for an increasing proportion of the typical intensive
care unit (ICU) case-mix. Because of the increased availability of new drugs for cancer and …

Pseudomonas aeruginosa is a major nosocomial pathogen that causes severe disease
including sepsis. Carbapenem-resistant P. aeruginosa is recognised by the World Health …

The increasing global threat of antibiotic resistance, which has resulted in countless fatalities
due to untreatable infections, underscores the urgent need for a strategic action plan. The …

Background Healthcare-associated infections involving Gram-negative bacteria (GNB) with
difficult-to-treat resistance (DTR) phenotype are associated with impaired patient-centered …

Purpose We aim to evaluate the association between central venous catheter (CVC)
insertion site and microbiological CVC complications in a nationwide cohort. Methods This …

Background and objectives Klebsiella pneumoniae (K. pneumoniae) is the second leading
cause of community-acquired and hospital-acquired gram-negative bloodstream infection …

Few data are available on incidence of multidrug-resistant organism (MDRO) colonization
and infections in mechanically ventilated patients, particularly during the COVID-19 …

Severe infections caused by DTR-GNB pose a formidable challenge for healthcare
providers and represent a growing global health issue. The proper administration and …

Carbapenem resistance in difficult-to-treat P. aeruginosa (DTR-PA) strains is primarily
mediated by loss or reduction of the OprD porin, overexpression of the cephalosporinase …